Cardiooncology-dealing with modern drug treatment, long-term complications, and cancer survivorship

被引：8

作者：

de Wall, Claudia ^{[1
]}

Bauersachs, Johann ^{[1
]}

Berliner, Dominik ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Cardiol & Angiol, Carl Neuberg Str 1, D-30625 Hannover, Germany

来源：

CLINICAL & EXPERIMENTAL METASTASIS | 2021年 / 38卷 / 04期

关键词：

Cardio-oncology; Cardiotoxicity; Myocardial dysfunction; Cancer survivorship; Long-term complications; Chemotherapy; LEFT-VENTRICULAR DYSFUNCTION; ISCHEMIC-HEART-DISEASE; BREAST-CANCER; AMERICAN SOCIETY; CARDIOVASCULAR COMPLICATIONS; EUROPEAN ASSOCIATION; EJECTION FRACTION; EXPERT CONSENSUS; TROPONIN-I; CARDIOTOXICITY;

D O I：

10.1007/s10585-021-10106-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Modern treatment strategies have improved prognosis and survival of patients with malignant diseases. The key components of tumor treatment are conventional chemotherapy, radiotherapy, targeted therapies, and immunotherapy. Cardiovascular side-effects may occur in the early phase of tumor therapy or even decades later. Therefore, knowledge and awareness of acute and long-lasting cardiac side effects of anti-cancer therapies are essential. Cardiotoxicity impairs quality of life and overall survival. The new cardiologic subspecialty 'cardio-oncology' deals with the different cardiovascular problems arising from tumor treatment and the relationship between cancer and heart diseases. Early detection and treatment of cardiotoxicity is of crucial importance. A detailed cardiac assessment of patients prior to administration of cardiotoxic agents, during and after treatment should be performed in all patients. The current review focusses on acute and long-term cardiotoxic side effects of classical cytotoxic and selected modern drug treatments such as immune checkpoint inhibitors and discusses strategies for the diagnosis of treatment-related adverse cardiovascular effects in cancer patients.

引用

页码：361 / 371

页数：11

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