Traditional Chinese medicine Dingkun Pill facilitates uterine receptivity for implantation in mice

被引：9

作者：

Huang, Lin ^{[1
,2
]}

Wang, Lemeng ^{[1
,2
]}

Bao, Haili ^{[1
,2
]}

Xu, Yingchun ^{[1
,2
]}

Meng, Meiqing ^{[1
,2
]}

Qiao, Manting ^{[1
,2
]}

Wang, Haibin ^{[1
,2
]}

Kong, Shuangbo ^{[1
,2
]}

机构：

[1] Xiamen Univ, Affiliated Hosp 1, Reprod Med Ctr, Xiamen, Fujian, Peoples R China

[2] Xiamen Univ, Sch Med, Fujian Prov Key Lab Reprod Hlth Res, Xiamen, Fujian, Peoples R China

来源：

BIOLOGY OF REPRODUCTION | 2019年 / 101卷 / 04期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Dingkun Pill (DK); uterine receptivity; implantation; estrogen; LEUKEMIA INHIBITORY FACTOR; BLASTOCYST IMPLANTATION; MOUSE UTERUS; E-CADHERIN; EMBRYO; ENDOMETRIUM; EXPRESSION; EPITHELIUM; TIME; ESTROGEN;

D O I：

10.1093/biolre/ioz141

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dingkun Pill (DK) is one of the representative traditional Chinese medicines, which has been used in the treatment of gynecological diseases for hundreds of years. Accumulative observations and evidence have shown the beneficial effects of DK, including enhancing the function of hypothalamic-pituitary-ovarian axis. However, the underlying mechanisms remain elusive. In this study, the effects of DK on uterine receptivity and implantation were explored by a series of studies with different mouse models. The results showed that DK can advance the time of implantation by influencing the expression of estrogen target genes to facilitate embryo implantation. DK was efficient to activate embryo implantation at the presence of suboptimal estrogen in delayed implantation mouse model. Our further study revealed that the improvement of DK on receptivity establishment is attributed to the differential regulation of DK on implantation-associated genes. This study provides previously unappreciated molecular mechanism of DK in embryo implantation and benefits the potential clinical application of DK in human reproduction improvement. Summary Sentence Dingkun Pill (DK), one of the representative traditional Chinese medicines, facilitates the establishment of uterine receptivity through enhancing the estrogen sensitivity.

引用

页码：695 / 703

页数：9

共 39 条

[1] Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions [J].