Efficacy is Not Everything: Eliciting Women's Preferences for a Vaginal HIV Prevention Product Using a Discrete-Choice Experiment

被引:32
作者
Browne, Erica N. [1 ]
Montgomery, Elizabeth T. [1 ]
Mansfield, Carol [2 ]
Boeri, Marco [2 ]
Mange, Brennan [2 ]
Beksinska, Mags [3 ]
Schwartz, Jill L. [4 ]
Clark, Meredith R. [4 ]
Doncel, Gustavo F. [4 ]
Smit, Jenni [3 ]
Chirenje, Zvavahera M. [5 ]
van der Straten, Ariane [1 ,6 ]
机构
[1] RTI Int, Womens Global Hlth Imperat, 351 Calif St,Suite 500, San Francisco, CA 94104 USA
[2] RTI Int, Hlth Solut, Res Triangle Pk, NC USA
[3] Univ Witwatersrand, Fac Hlth Sci, MRU, Durban, South Africa
[4] Eastern Virginia Med Sch, CONRAD, Arlington, VA USA
[5] Univ Zimbabwe, Coll Hlth Sci, Clin Trials Res Ctr, Harare, Zimbabwe
[6] Univ Calif San Francisco, Dept Med, Ctr AIDS Prevent Studies, San Francisco, CA 94143 USA
基金
比尔及梅琳达.盖茨基金会;
关键词
HIV prevention; Discrete-choice experiment; South Africa; Zimbabwe; Women; PREEXPOSURE PROPHYLAXIS; ACCEPTABILITY; INFECTION; CONDOMS; SAFETY; SAMPLE; RING; MEN; GEL;
D O I
10.1007/s10461-019-02715-1
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
As new female-initiated HIV prevention products enter development, it is crucial to incorporate women's preferences to ensure products will be desired, accepted, and used. A discrete-choice experiment was designed to assess the relative importance of six attributes to stated choice of a vaginally delivered HIV prevention product. Sexually active women in South Africa and Zimbabwe aged 18-30 were recruited from two samples: product-experienced women from a randomized trial of four vaginal placebo forms and product-naive community members. In a tablet-administered survey, 395 women chose between two hypothetical products over eight choice sets. Efficacy was the most important, but there were identifiable preferences among other attributes. Women preferred a product that also prevented pregnancy and caused some wetness (p<0.001). They disliked a daily-use product (p=0.002) and insertion by finger (p=0.002). Although efficacy drove preference, wetness, pregnancy prevention, and dosing regimen were influential to stated choice of a product, and women were willing to trade some level of efficacy to have other more desired attributes.
引用
收藏
页码:1443 / 1451
页数:9
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