Pleuropulmonary paragonimiasis due to Paragonimus heterotremus:: molecular diagnosis, prevalence of infection and clinicoradiological features in an endemic area of northeastern India

被引:40
作者
Devi, K. Rekha
Narain, Kanwar
Bhattacharya, S.
Negmu, K.
Agatsuma, Takeshi
Blair, David
Wickramashinghe, S.
Mahanta, J.
机构
[1] NE Reg Indian Council Med Res, Reg Med Res Ctr, Dibrugarh 786001, Assam, India
[2] Community Hlth Ctr, Miao, Arunachal Prade, India
[3] Kochi Med Sch, Dept Environm Hlth Sci, Nankoku, Kochi 7838505, Japan
[4] James Cook Univ N Queensland, Sch Trop Biol, Townsville, Qld 4811, Australia
关键词
paragonimiasis; Paragonimus heterotremus; prevalence; sequencing; internal transcribed spacers; phylogenetic analysis; India;
D O I
10.1016/j.trstmh.2007.02.028
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
In the northeastern region of India, paragonimiasis is emerging as an important public health problem. However, until now the identity of the species causing human infection has been uncertain and there has been little information on the prevalence and clinicoradiological features of infection in the community. Parasitological and immunological surveys revealed that paragonimiasis was hyperendemic in parts of Arunachal Pradesh. Egg positivity in the sputum was 20.9% and 4.1% in children (age <= 15 years) and adults (age > 15 years), respectively. Antibody positivity against excretory-secretory antigen of the adult worm in children and adults was 51.7% and 18.7%, respectively. Chronic cough (97.2%) and haemoptysis (83.3%) were common respiratory symptoms among egg-positive cases. Chest radiography (n = 68) images from egg-positive cases showed that air space consolidation (75%), cavitary Lesions (14.7%) and mediastinal adenopathy (11.8%) were very frequent. Less frequent findings were nodular lesions, bronchiectasis, mediastinal adenopathy, pleural thickening and pleural effusion. DNA extracted from eggs from the sputum of patients from Arunachal Pradesh was sequenced. Analyses of the second internal transcribed spacer (ITS2) of nuctear rDNA revealed that the species responsible is Paragonimus heterotremus. (D 2007 Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene.
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页码:786 / 792
页数:7
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