Enhanced glutamic acid production of Brevibacterium sp with temperature shift-up cultivation

被引：3

作者：

Choi, SU ^{[1
]}

Nihira, T ^{[1
]}

Yoshida, T ^{[1
]}

机构：

[1] Osaka Univ, Int Ctr Biotechnol, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 2004年 / 98卷 / 03期

关键词：

glutamic acid; efflux; biotin limitation; shift-up;

D O I：

10.1016/S1389-1723(04)00268-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

For cells of Brevibacterium sp. under conditions of biotin limitation, the efflux of metabolites through the cell membrane was affected by temperature. After the temperature shift-up from 30degreesC to 38degreesC, both the specific production rate of glutamic acid and the excretion of intracellular materials, such as glucose-6-phosphate and nucleotides, were increased simultaneously. For the production of glutamic acid, not only the yield but also the specific production rate was increased by the temperature shift-up.

引用

页码：211 / 213

页数：3

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