Concise Review: Bone Marrow-Derived Stem/Progenitor Cells in Cutaneous Repair and Regeneration

被引：210
|
作者：
Wu, Yaojiong [2 ]
Zhao, Robert C. H. [1 ,3 ]
Tredget, Edward E. [4 ]
机构：
[1] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Excellence Tissue Engn, Dept Cell Biol, Beijing 100730, Peoples R China
[2] Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Beijing 100084, Peoples R China
[3] Peking Union Med Coll, Sch Basic Med, Beijing 100021, Peoples R China
[4] Univ Alberta, Dept Surg, Wound Healing Res Grp, Edmonton, AB, Canada
来源：
STEM CELLS | 2010年 / 28卷 / 05期
关键词：
Cutaneous regeneration; Wound healing; Mesenchymal stem cells; Fibrocytes; Endothelial progenitor cells; MESENCHYMAL STEM-CELLS; ENDOTHELIAL PROGENITOR CELLS; PERIPHERAL-BLOOD; STROMAL CELLS; CIRCULATING FIBROCYTES; UMBILICAL-CORD; EXPRESSION ANALYSIS; GENE-EXPRESSION; WOUNDED SKIN; IN-VIVO;
D O I：
10.1002/stem.420
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Our understanding of the role of bone marrow (BM)derived cells in cutaneous homeostasis and wound healing had long been limited to the contribution of inflammatory cells. Recent studies, however, suggest that the BM contributes a significant proportion of noninflammatory cells to the skin, which are present primarily in the dermis in fibroblast-like morphology and in the epidermis in a keratinocyte phenotype; and the number of these BM-derived cells increases markedly after wounding. More recently, several studies indicate that mesenchymal stem cells derived from the BM could significantly impact wound healing in diabetic and nondiabetic animals, through cell differentiation and the release of paracrine factors, implying a profound therapeutic potential. This review discusses the most recent understanding of the contribution of BM-derived noninflammatory cells to cutaneous homeostasis and wound healing. STEM CELLS 2010; 28: 905-915
引用
收藏
页码：905 / 915
页数：11
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