Oxidative stress in keratinocytes as an etiopathogenetic factor of psoriasis

被引：31
作者：
Shilov, VN [1 ]
Sergienko, VI [1 ]
机构：
[1] Russian Minist Hlth, Inst Physicochem Med, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2000年 / 129卷 / 04期
关键词：
psoriasis; apoptosis; inflammation; proliferation; oxidative stress; lipid peroxidation; reactive oxygen species; redox potential;
D O I：
10.1007/BF02439252
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A new etiopathogenetic concept of psoriasis is proposed, which considers psoriasis as a typical inflammatory process characterized by increased antioxidant activity and overexpression of apoptotic receptors. Under these conditions, hyperstimulation of germinative layer cells proliferation dramatically accelerates keratinocyte passage towards apoptotic effect of atmospheric oxygen and its reactive species dooming to death cells with enhanced expression of apoptotic receptors. Oxidative stress of nondifferentiated keratinocytes triggers the formation of defective horny layer, the key mechanism of psoriasis.
引用
收藏
页码：309 / 313
页数：5
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