Development of Biomimetic Chitosan-Based Hydrogels Using an Elastin-Like Polymer

被引：17

作者：

Barbosa, Joaquim S. ^{[1
]}

Ribeiro, Artur ^{[3
]}

Testera, Ana M. ^{[3
]}

Alonso, Matilde ^{[3
]}

Arias, Francisco J. ^{[3
]}

Rodriguez-Cabello, Jose C. ^{[2
,3
]}

Mano, Joao F. ^{[1
]}

机构：

[1] 3Bs Res Grp Biomat Biodegradables & Biomimet, P-4806909 Caldas Das Taipas, Guimaraes, Portugal

[2] Univ Valladolid, GIR Bioforge, E-47011 Valladolid, Spain

[3] Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Valladolid, Spain

来源：

ADVANCED ENGINEERING MATERIALS | 2010年 / 12卷 / 1-2期

关键词：

IN-VITRO CHARACTERIZATION; ALTERNATE SOAKING PROCESS; BIOMEDICAL APPLICATIONS; CONTROLLED-RELEASE; SCAFFOLD DESIGN; BONE; TEMPERATURE; CARTILAGE; MATRICES; SYSTEMS;

D O I：

10.1002/adem.200980152

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Chitosan and an elastin-like polymer, containing a specific osteoconductive sequence in the primary structure, have been combined to obtain bioactive injectable systems with enhanced mechanical properties and hydrogels. Obtained results indicate that the combination of such polymers may be very promising in the development of biomaterials for minimal invasive orthopaedic reconstructive applications or in bone tissue engineering. The figure shows a thermo-sensitive hydrogel, with a gelation point under physiological temperature. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：B37 / B44

页数：8

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