Assessment of False-negative Ascites Cytology in Epithelial Ovarian Carcinoma A Study of 313 Patients

被引:11
作者
Allen, Valerie A. [2 ]
Takashima, Yoko [2 ]
Nayak, Seema [2 ]
Manahan, Kelly J. [1 ,2 ]
Geisler, John P. [1 ,2 ]
机构
[1] Univ Toledo, Coll Med & Life Sci, Div Gynecol Oncol, 2801 W Bancroft St, Toledo, OH 43606 USA
[2] Univ Toledo, Coll Med & Life Sci, Dept Obstet & Gynecol, 2801 W Bancroft St, Toledo, OH 43606 USA
来源
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 2017年 / 40卷 / 02期
关键词
ovarian cancer; peritoneal cytology; paracentesis; PERITONEAL WASHING CYTOLOGY; MALIGNANT ASCITES; FLUID ANALYSIS; CANCER;
D O I
10.1097/COC.0000000000000119
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: The objective was to determine how often peritoneal cytology is positive for malignancy in women with known ovarian cancer. Knowing this fact would help determine the usefulness of diagnostic paracentesis. Methods: Records of all women diagnosed with invasive epithelial ovarian cancer from 2004 to 2012 were examined to correlate presence of ascites, cytologic, and pathologic findings. Results: A total of 313 patients were included in analysis. A total of 210 of 313 patients (67.1%) with ascites had cytology positive for malignancy. This left 103 patients with ascites and cancer without malignant cells found in the ascites removed at the time of surgery. Conclusions: Except in a few cases, paracentesis is not recommended for the diagnosis of ovarian cancer because of the potential spreading of cancer. Furthermore, with only just over two thirds of cases of known cancer and ascites having cytology positive for malignancy, the value of paracentesis for diagnosis of ovarian cancer is minimal.
引用
收藏
页码:175 / 177
页数:3
相关论文
共 23 条
[1]   Malignant ascites: Past, present, and future [J].
Adam, RA ;
Adam, YG .
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2004, 198 (06) :999-1011
[2]  
Anderson B, 2000, J GYNECOL SURG, V16, P113
[3]  
COLLI A, 1993, CANCER, V72, P677, DOI 10.1002/1097-0142(19930801)72:3<677::AID-CNCR2820720309>3.0.CO
[4]  
2-C
[5]  
DiSaia PJ, 1997, CLIN GYNECOLOGIC ONC, V5th, P282
[6]   Dissemination of intraperitoneal ovarian cancer: Discussion of mechanisms and demonstration of lymphatic spreading in ovarian cancer model [J].
Feki, Anis ;
Berardi, Philip ;
Bellingan, Geoff ;
Major, Attila ;
Krause, Karl-Heinz ;
Petignat, Patrick ;
Zehra, Rubab ;
Pervaiz, Shazib ;
Irminger-Finger, Irmgard .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2009, 72 (01) :1-9
[7]  
Geisler J P, 2004, Minerva Ginecol, V56, P539
[8]   Nutritional assessment using prealbumin as an objective criterion to determine whom should not undergo primary radical cytoreductive surgery for ovarian cancer [J].
Geisler, John P. ;
Linnemeier, Georgiann C. ;
Thomas, Amanda J. ;
Manahan, Kelly J. .
GYNECOLOGIC ONCOLOGY, 2007, 106 (01) :128-131
[9]   Recent Progress in the Diagnosis and Treatment of Ovarian Cancer [J].
Jelovac, Danijela ;
Armstrong, Deborah K. .
CA-A CANCER JOURNAL FOR CLINICIANS, 2011, 61 (03) :183-203
[10]   How valuable is ascitic cytology in the detection and management of malignancy? [J].
Karoo, ROS ;
Lloyd, TDR ;
Garcea, G ;
Redway, HD ;
Robertson, GSR .
POSTGRADUATE MEDICAL JOURNAL, 2003, 79 (931) :292-294