An efficient hydration of nitriles with ruthenium-supported heterogeneous catalyst in water under moderate conditions

被引：9

作者：

Hussain, Muhammad Asif ^{[1
,2
]}

Choi, Eun Ju ^{[2
]}

Maqbool, Adnan ^{[1
]}

Atif, Muhammad ^{[3
]}

Zeb, Hassan ^{[4
]}

Yeo, JaeGoo ^{[2
]}

Yu, Jung-A ^{[2
]}

Cho, Yong-Hun ^{[2
]}

Noh, Moses ^{[5
]}

Kim, Jung Won ^{[2
]}

机构：

[1] Univ Engn & Technol, Dept Met & Mat Engn, Lahore 39161, Pakistan

[2] Kangwon Natl Univ, Dept Chem Engn, Samcheok 25913, Gangwon Do, South Korea

[3] Univ Educ Lahore, DS&T, Dept Chem, Vehari Campus, Punjab, Pakistan

[4] Univ Punjab, Inst Energy & Environm Engn, Lahore, Pakistan

[5] Drexel Univ, Dept Mech Engn & Mech, 3141 Chestnut St, Philadelphia, PA 19104 USA

来源：

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2021年 / 99卷

基金：

新加坡国家研究基金会;

关键词：

Ruthenium; Manganese oxide; Hydration; Water; Nitrile; Amide; NANOROD MANGANESE OXIDE; SELECTIVE HYDRATION; AEROBIC OXIDATION; AMIDE SYNTHESIS; ALCOHOLS; AMINES; HYDROXYAPATITE; NANOPARTICLES; NANOCATALYST; ACTIVATION;

D O I：

10.1016/j.jiec.2021.04.025

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile eco-friendly heterogeneous catalytic system has been developed for amide synthesis that further utilized in pharmaceutical and organic chemistry. The Ru/MnO2 catalyst has shown outstanding and unprecedented activity for a wide range of aliphatic and benzylic nitriles in green solvent water at 60 degrees C. The system has also exhibited a remarkable tolerance for selective hydration of heteroatom (e.g. nitrogen, oxygen and sulphur atoms) containing nitriles. Pharmaceutically important nicotinamides and pyrazinamide has been synthesized by hydration of the heteroatomic nitriles with appreciable yields and selectivities. Moreover, the Ru/MnO2 catalyst has employed water as a benign solvent, with more than 30,000 TONs and reusability five times after isolation from the reaction mixture by centrifugation and easy workup that established a path for green environmental and technologically acceptable protocol. (C) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

引用

页码：187 / 195

页数：9

共 63 条

[1] Metal-catalysed approaches to amide bond formation [J].