Structure-based design and synthesis of a potent matrix metalloproteinase-13 inhibitor based on a pyrrolidinone scaffold

被引：39

作者：

Robinson, RP ^{[1
]}

Laird, ER ^{[1
]}

Blake, JF ^{[1
]}

Bordner, J ^{[1
]}

Donahue, KM ^{[1
]}

Lopresti-Morrow, LL ^{[1
]}

Mitchell, PG ^{[1
]}

Reese, MR ^{[1
]}

Reeves, LM ^{[1
]}

Stam, EJ ^{[1
]}

Yocum, SA ^{[1
]}

机构：

[1] Pfizer Inc, Div Cent Res, Groton, CT 06340 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2000年 / 43卷 / 12期

关键词：

D O I：

10.1021/jm0001368

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2293 / 2296

页数：4

共 27 条

[1] STROMELYSIN-1 - 3-DIMENSIONAL STRUCTURE OF THE INHIBITED CATALYTIC DOMAIN AND OF THE C-TRUNCATED PROENZYME [J].

BECKER, JW ;

MARCY, AI ;

ROKOSZ, LL ;

AXEL, MG ;

BURBAUM, JJ ;

FITZGERALD, PMD ;

CAMERON, PM ;

ESSER, CK ;

HAGMANN, WK ;

HERMES, JD ;

SPRINGER, JP .

PROTEIN SCIENCE, 1995, 4 (10) :1966-1976

[2] Matrix metalloproteinase inhibitors 1998 [J].

Beckett, RP ;

Whittaker, M .

EXPERT OPINION ON THERAPEUTIC PATENTS, 1998, 8 (03) :259-282

[3]

Blake J., UNPUB

[4] THE X-RAY CRYSTAL-STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN NEUTROPHIL COLLAGENASE INHIBITED BY A SUBSTRATE-ANALOG REVEALS THE ESSENTIALS FOR CATALYSIS AND SPECIFICITY [J].

BODE, W ;

REINEMER, P ;

HUBER, R ;

KLEINE, T ;

SCHNIERER, S ;

TSCHESCHE, H .

EMBO JOURNAL, 1994, 13 (06) :1263-1269

[5] STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR [J].

BORKAKOTI, N ;

WINKLER, FK ;

WILLIAMS, DH ;

DARCY, A ;

BROADHURST, MJ ;

BROWN, PA ;

JOHNSON, WH ;

MURRAY, EJ .

NATURE STRUCTURAL BIOLOGY, 1994, 1 (02) :106-110

[6] Matrix metalloproteinase inhibitors in arthritis [J].

Bottomley, KM ;

Johnson, WH ;

Walter, DS .

JOURNAL OF ENZYME INHIBITION, 1998, 13 (02) :79-101

[7] MATRILYSIN-INHIBITOR COMPLEXES - COMMON THEMES AMONG METALLOPROTEASES [J].

BROWNER, MF ;

SMITH, WW ;

CASTELHANO, AL .

BIOCHEMISTRY, 1995, 34 (20) :6602-6610

[8] Directed ortho metalation of neopentyl benzoates with LDA: Preparation of arylboronic acids [J].

Caron, S ;

Hawkins, JM .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (07) :2054-2055

[9] Crystal structure of the stromelysin catalytic domain at 2.0 Å resolution:: Inhibitor-induced conformational changes [J].

Chen, LY ;

Rydel, TJ ;

Gu, F ;

Dunaway, CM ;

Pikul, S ;

Dunham, KM ;

Barnett, BL .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 293 (03) :545-557

[10]

DUAN J, 1999, Patent No. 18074

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