Regulation Mechanisms of Viral IRES-Driven Translation

被引：136

作者：

Lee, Kuo-Ming ^{[1
]}

Chen, Chi-Jene ^{[1
]}

Shih, Shin-Ru ^{[1
,2
,3
]}

机构：

[1] Chang Gung Univ, Coll Med, Dept Med Biotechnol & Lab Sci, Taoyuan, Taiwan

[2] Chang Gung Univ, Coll Med, Res Ctr Emerging Viral Infect, Taoyuan, Taiwan

[3] Chang Gung Mem Hosp, Dept Lab Sci, Clin Virol Lab, Taoyuan, Taiwan

来源：

TRENDS IN MICROBIOLOGY | 2017年 / 25卷 / 07期

关键词：

RIBOSOME ENTRY SITE; C VIRUS-RNA; TRACT-BINDING-PROTEIN; MESSENGER-RNA; INTERNAL INITIATION; ENTEROVIRUS; 71; DEPENDENT TRANSLATION; MEDIATED TRANSLATION; POLIOVIRUS RNA; 5'-UNTRANSLATED REGION;

D O I：

10.1016/j.tim.2017.01.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Internal ribosome entry sites (IRESs) can be found in the mRNA of many viruses as well as in cellular genes involved in the stress response, cell cycle, and apoptosis. IRES-mediated translation can occur when dominant cap-dependent translation is inhibited, and viruses can take advantage of this to subvert host translation machinery. In this review, we focus on the four major types of IRES identified in RNA viruses, and outline their distinct structural properties and requirements of translational factors. We further discuss auxiliary host factors known as IRES trans-acting factors (ITAFs), which are involved in the modulation of optimal IRES activity. Currently known strategies employed by viruses to harness ITAFs and regulate IRES activity are also highlighted.

引用

页码：547 / 562

页数：16

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