A study of serum Apo A-1 and Apo B-100 levels in women with preeclampsia

Objective: To investigate Apo A-1 and Apo B-100 levels and Apo B-100/Apo A-1 ratios in preeclamptic (PE) patients. Materials and methods: Forty-eight PE and 48 without PE patients (healthy pregnancies) matched for gestational age were included. Maternal age, parity, gestational age at delivery, obstetrical complications including intrauterine growth restriction (IUGR) and gestational diabetes mellitus (GDM), serum Apo A-1 and Apo B-100 levels, and the Apo B-100/Apo A-1 ratio were compared. Results: Preeclamptic patients had significantly lower Apo A-1 levels (167.07 mg/dl +/- 14.61 mg/dl vs. 244.37 mg/dl +/- 20.84 mg/dl, p < 0.001), higher Apo B-100/Apo A-1 ratio (0.63 +/- 0.07 vs. 0.42 +/- 0.05, p < 0.001), but similar Apo B-100 levels (104.84 mg/dl +/- 7.05 mg/dl vs. 102.39 mg/dl +/- 8.08 mg/dl, p = 0.118). Mean Apo A-1 and Apo B-100 levels and the Apo B-100/Apo A-1 ratio were similar in patients with severe PE, HELLP syndrome, IUGR, and patients requiring antihypertensive therapy compared to PE patients who did not have these complications (p > 0.05). Apo A-1 levels had the best accuracy followed by the Apo B-100/Apo A-1 ratio in patients with PE. Conclusion: Apo A-1 and the Apo B-100/Apo A-1 ratio may be useful markers in patients with PE. Further studies are required to elucidate this issue. (C) 2016 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.