Toxoplasmosis accelerates acquisition of epilepsy in rats undergoing chemical kindling

被引：13

作者：

Babaie, Jalal ^{[1
,2
]}

Sayyah, Mohammad ^{[1
]}

Choopani, Samira ^{[1
]}

Asgari, Tara ^{[1
]}

Golkar, Majid ^{[2
]}

Gharagozli, Kourosh ^{[3
]}

机构：

[1] Pasteur Inst Iran, Dept Physiol & Pharmacol, Tehran 1316943551, Iran

[2] Pasteur Inst Iran, Dept Parasitol, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Dept Neurol, Tehran, Iran

来源：

EPILEPSY RESEARCH | 2017年 / 135卷

关键词：

Toxoplasma gondii; Pentylenetetrazole; Kindling; Rat; Epileptogenesis; CRYPTOGENIC EPILEPSY; GONDII INFECTION; MICE; BEHAVIOR; PREVALENCE; AGE;

D O I：

10.1016/j.eplepsyres.2017.06.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Epilepsy is one of the most common neurologic disorders worldwide with no distinguishable cause in 60% of patients. One-third of the world population has been infected with Toxoplasma gondii. This intracellular parasite has high tropism for excitable cells including neurons. We assessed impact of acute and chronic T. gondii infection on epileptogenesis in pentylenetetrazole (PTZ) kindling model in male rats. T. gondii cysts were administered to rats by intraperitoneal (i.p.) injection. The presence of T. gondii cysts in the brain of rats was verified by hematoxylin-eosin staining. One and eight weeks after cysts injection, as acute and chronic phases of infection, PTZ (30 mg/kg, i.p.) was injected to the rats every other day until manifestation of generalized seizures. Histologic findings confirmed cerebral toxoplasmosis in rats. The rats with acute or chronic Toxoplasma infection became kindled by lower number of PTZ injections (14.8 1 and 13.6 1 injections, respectively) compared to corresponding uninfected rats (18.7 1 and 16.9 1 injections, p < 0.05). Toxoplasma infection increased the rate of kindling in rats. The chronically-infected rats achieved focal and also generalized seizures earlier than the rats with acute infection. Toxoplasmosis might be considered as a risk factor for acquisition of epilepsy.

引用

页码：137 / 142

页数：6

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