The Effectiveness of Endoscopic Gastroplasty for Obesity Treatment According to FDA Thresholds: Systematic Review and Meta-Analysis Based on Randomized Controlled Trials

被引：11

作者：

Madruga-Neto, Antonio Coutinho ^{[1
]}

Bernardo, Wanderley Marques ^{[1
]}

Hourneaux de Moura, Diogo Turiani ^{[1
]}

Brunaldi, Vitor Ottoboni ^{[1
]}

Martins, Rafael Krieger ^{[1
]}

Josino, Iatagan Rocha ^{[1
]}

Hourneaux de Moura, Eduardo Turiani ^{[1
]}

de Souza, Thiago Ferreira ^{[1
]}

Santo, Marco Aurelio ^{[2
]}

Hourneaux de Moura, Eduardo Guimares ^{[1
]}

机构：

[1] Univ Sao Paulo, Hosp Clin, Med Sch, Gastrointestinal Endoscopy Unit, Dr Arnaldo Av 455, BR-01246903 Sao Paulo, Brazil

[2] Univ Sao Paulo, Hosp Clin, Med Sch, Bariatr & Metab Surg Unit, Sao Paulo, Brazil

来源：

OBESITY SURGERY | 2018年 / 28卷 / 09期

关键词：

Obesity; Gastroplasty; Endoscopy; Endoluminal therapy; Endoscopic therapy; Endoscopic suture; Systematic review; Meta-analysis; LAPAROSCOPIC SLEEVE GASTRECTOMY; LIFE-STYLE INTERVENTION; BARIATRIC SURGERY; WEIGHT-LOSS; INTRAGASTRIC BALLOON; METABOLIC THERAPIES; MEDICAL THERAPY; TERM OUTCOMES; QUALITY; SAFETY;

D O I：

10.1007/s11695-018-3335-4

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Endoscopic bariatric therapies (EBTs) are promising alternatives to conventional surgery for obesity. The aim of this study is to compare efficacy and safety through a systematic review and meta-analysis of the endoscopic gastroplasty techniques versus conservative treatment. We searched MEDLINE, EMBASE, Cochrane CENTRAL, Lilacs/Bireme. Randomized controlled trials (RCTs) enrolling obese patients comparing endoscopic gastroplasty to sham or diet/exercise were considered eligible. Among 6014 records, three RCTs were selected for meta-analysis. The total sample was 459 patients (312 EBTs vs 147 control). Mean total body weight loss in the intervention group (IG) was 4.8% higher than the control group (CG) at 12 months (p = 0.01). The IG responder rate was 44.31% at 12 months. Therefore, the endoscopic gastroplasty is more effective than conservative therapies but do not achieve FDA thresholds.

引用

页码：2932 / 2940

页数：9

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