Upregulation of SIRT1 contributes to the cardioprotective effect of Rutin against myocardial ischemia-reperfusion injury in rats

被引：27

作者：

Lin, Qiao ^{[1
,2
,3
]}

Chen, Xiu-Ying ^{[1
,2
,3
]}

Zhang, Ji ^{[4
]}

Yuan, Yong-Liang ^{[4
]}

Zhao, Wen ^{[1
,2
,3
]}

Wei, Bo ^{[1
,2
,3
]}

机构：

[1] Zhengzhou Univ, Minist Educ China, Key Lab Adv Drug Preparat Technol, Zhengzhou 450001, Henan, Peoples R China

[2] Zhengzhou Univ, Coinnovat Ctr Henan Prov New Drug R&D & Preclin S, Zhengzhou 450001, Henan, Peoples R China

[3] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China

[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Pharm, Henan Key Lab Precis Clin Pharm, Zhengzhou 450052, Henan, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 46卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Rutin; SIRT1; Nrf2; Oxidative stress; Myocardial ischemia reperfusion; TANSHINONE IIA SULFONATE; OXIDATIVE STRESS; ISCHEMIA/REPERFUSION INJURY; PROTECTS; PATHWAY; ACTIVATION; CARDIOMYOPATHY; INFARCTION; DYSFUNCTION; INHIBITION;

D O I：

10.1016/j.jff.2018.05.007

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The mechanisms underlying beneficial actions of Rutin, a food derived-polyphenolic bioflavonoid, against myocardial ischemia-reperfusion (MI/R) injury were detected. We found that Rutin could significantly ameliorate infarct size and attenuate cardiac dysfunctionto in some extent. Additionally, Rutin could also improve variation of myocardial zymogram and up-regulate antioxidant systems in heart. The selective SIRT1 inhibitor, Ex-527, exacerbated MI/R injury as evidenced by further increased oxidative stress and infracted area in heart tissue. Importantly, Ex-527 abolished the cardioprotective effect of Rutin in MI/R rats. Docking analysis further demonstrated the vital role of SIRT1 on Rutin's cardioprotective effect. We found that activation of SIRT1/Nrf2 signaling induced by Rutin contributes to the reduced oxidative stress, along with decreased apoptosis of cardiomyocytes in heart tissue. Overall, our findings suggest that SIRT1/Nrf2 signaling pathway may be a potential therapeutic target for the treatment of oxidative stress and apoptosis related myocardial diseases.

引用

页码：227 / 236

页数：10

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