The simultaneous presence of multiple spinal neural tube defects is unusual. There have been only a few of these cases reported in the literature. The authors report on three cases of double spina bifida cystica. One patient had two myelomeningoceles (MMCs) at the cervical and lumbosacral regions, one was noted to have both thoracolumbar and sacral defects, and the third presented with double NIMCs at lumbar and lumbosacral levels. All three neonates in these cases underwent surgical treatment and ventriculoperitoneal (VP) shunt insertion for associated hydrocephalus. One child died at the age of 2 months despite a well-functioning VP shunt. The other two patients had no complications. Current models of neural tube closure do not thoroughly explain the mechanisms of multiple spinal dysraphism, but the multisite closure model provides a better understanding of caudal neural tube closure than other closure-site models.
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Istanbul Univ, Cerrahpasa Med Fac, Div Neuroradiol, Dept Radiol, Istanbul, TurkeyIstanbul Univ, Cerrahpasa Med Fac, Div Neuroradiol, Dept Radiol, Istanbul, Turkey
Islak, Civan
Kandemirli, Sedat Giray
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Istanbul Univ, Cerrahpasa Med Fac, Div Neuroradiol, Dept Radiol, Istanbul, TurkeyIstanbul Univ, Cerrahpasa Med Fac, Div Neuroradiol, Dept Radiol, Istanbul, Turkey
Kandemirli, Sedat Giray
Kizilkilic, Osman
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Istanbul Univ, Cerrahpasa Med Fac, Div Neuroradiol, Dept Radiol, Istanbul, TurkeyIstanbul Univ, Cerrahpasa Med Fac, Div Neuroradiol, Dept Radiol, Istanbul, Turkey
Kizilkilic, Osman
Kocer, Naci
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Istanbul Univ, Cerrahpasa Med Fac, Div Neuroradiol, Dept Radiol, Istanbul, TurkeyIstanbul Univ, Cerrahpasa Med Fac, Div Neuroradiol, Dept Radiol, Istanbul, Turkey
Kocer, Naci
Tuzgen, Saffet
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Istanbul Univ, Cerrahpasa Med Fac, Dept Neurosurg, Istanbul, TurkeyIstanbul Univ, Cerrahpasa Med Fac, Div Neuroradiol, Dept Radiol, Istanbul, Turkey
Tuzgen, Saffet
Hanci, Mehmet Murat
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Istanbul Univ, Cerrahpasa Med Fac, Dept Neurosurg, Istanbul, TurkeyIstanbul Univ, Cerrahpasa Med Fac, Div Neuroradiol, Dept Radiol, Istanbul, Turkey
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Sanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, IndiaSanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, India
Ranjan, Nitish
Kumar, Ashutosh
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Sanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, IndiaSanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, India
Kumar, Ashutosh
Shukla, Abhishek
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Sanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, IndiaSanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, India
Shukla, Abhishek
Verma, Pawan Kumar
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Sanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, IndiaSanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, India
Verma, Pawan Kumar
Mehrotra, Anant
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Sanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, IndiaSanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, India
Mehrotra, Anant
Jaiswal, Awadhesh Kumar
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Sanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, IndiaSanjay Gandhi Post Grad Inst Med Sci, Dept Neurosurg, Lucknow 226014, India