Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin-induced model of liver injury

被引：37

作者：

Zou, Xueqing ^{[1
,2
]}

Wang, Yongmei ^{[3
]}

Peng, Cheng ^{[1
]}

Wang, Ben ^{[1
]}

Niu, Zhengchuan ^{[1
,4
]}

Li, Zequn ^{[1
,4
]}

Niu, Jun ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Gen Surg, 107 Wenhuaxi St, Jinan 250012, Shandong, Peoples R China

[2] Qingdao Univ, Affiliated Hosp, Dept Anesthesiol, Qingdao 266000, Shandong, Peoples R China

[3] Qingdao Univ, Affiliated Hosp, Ctr Diag & Treatment Breast Dis, Qingdao 266000, Shandong, Peoples R China

[4] Chinese Minist Educ & Publ Hlth, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2018年 / 42卷 / 04期

基金：

中国国家自然科学基金;

关键词：

oxaliplatin-associated liver injury; magnesium isoglycyrrhizinate; oxidative stress; interleukin-6; coagulation system; SINUSOIDAL OBSTRUCTION SYNDROME; HUMAN ENDOTHELIAL-CELLS; PLASMINOGEN-ACTIVATOR; ADJUVANT TREATMENT; COLORECTAL-CANCER; OXIDATIVE STRESS; UP-REGULATION; CHEMOTHERAPY; GLUTATHIONE; FLUOROURACIL;

D O I：

10.3892/ijmm.2018.3787

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Oxaliplatin is a core chemotherapeutic agent used for the treatment of colorectal liver metastasis; however, liver injury caused by oxaliplatin increases the risk of peri-operative morbidity and mortality. Magnesium isoglycyrrhizinate (MgiG) is a magnesium salt of 18-alpha glycyrrhizic acid stereo-isomer that has demonstrated liver-protective effects against toxins and hepatitis. In the present study, the liver-protective effect of MgiG against oxaliplatin-induced hepatic injury was examined in vitro and in vivo. The results demonstrated that MgiG had a protective effect against oxaliplatin-induced liver injury, as evidenced by the alleviation of hepatic pathological damage and transaminase levels. The protective effect of MgiG was demonstrated to be correlated with inhibition of oxidative stress, the interleukin-6 pathway and the coagulation system. Altogether, the present findings suggested that MgiG may have potential value in the clinical prevention and treatment of oxaliplatin-induced liver injury.

引用

页码：2020 / 2030

页数：11