Association study of DISC1 genetic variants with the risk of schizophrenia

被引：7
作者：
Luo, Xin [1 ]
Jin, Chunhui [1 ,2 ]
Zhou, Zhenhe [1 ]
Zhang, Fuquan [1 ]
Yuan, Jianmin [1 ]
Liu, Xiaowei [1 ]
Cheng, Zaohuo [1 ]
机构：
[1] Nanjing Med Univ, Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R China
[2] Jiangsu Inst Psychol, Wuxi, Jiangsu, Peoples R China
来源：
PSYCHIATRIC GENETICS | 2016年 / 26卷 / 03期
基金：
中国国家自然科学基金;
关键词：
association; Disrupted-in-Schizophrenia; 1; Han Chinese; schizophrenia; single nucleotide polymorphism; SAMPLE-SIZE CALCULATIONS; HAN CHINESE POPULATION; BIPOLAR DISORDER; POWER; LOCI;
D O I：
10.1097/YPG.0000000000000123
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Our previous study confirmed that the 'AA' genotype carriers of DISC1 single nucleotide polymorphism (SNP) rs821616 had a significantly increased risk for schizophrenia (SCZ) in comparison with noncarriers. To further explore the relationship of DISC1 genetic variants with the risk of SCZ in Han Chinese, we designed the present two-step study. We sequenced the promoter and untranslated regions of the DISC1 gene using genomic DNA of 100 SCZ patients and identified 17 SNPs. All SNPs were then genotyped and analyzed through a case-control study with 1154 healthy controls and 1447 patients. In an association analysis, neither allelic nor genotypic modeling indicated a significant association between the risk of SCZ and all SNPs. In addition, we observed that a two-marker haplotype was nominally associated with protection for SCZ (P=0.0476). The present findings, at least in part, provide some clues for further investigating the association of DISC1 variants with SCZ susceptibility. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
引用
收藏
页码：132 / 135
页数：4
相关论文
共 14 条
  • [1] Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes
    Carless, M. A.
    Glahn, D. C.
    Johnson, M. P.
    Curran, J. E.
    Bozaoglu, K.
    Dyer, T. D.
    Winkler, A. M.
    Cole, S. A.
    Almasy, L.
    MacCluer, J. W.
    Duggirala, R.
    Moses, E. K.
    Goering, H. H. H.
    Blangero, J.
    [J]. MOLECULAR PSYCHIATRY, 2011, 16 (11) : 1096 - 1104
  • [2] Power and sample size calculations for studies involving linear regression
    Dupont, WD
    Plummer, WD
    [J]. CONTROLLED CLINICAL TRIALS, 1998, 19 (06): : 589 - 601
  • [3] POWER AND SAMPLE-SIZE CALCULATIONS - A REVIEW AND COMPUTER-PROGRAM
    DUPONT, WD
    PLUMMER, WD
    [J]. CONTROLLED CLINICAL TRIALS, 1990, 11 (02): : 116 - 128
  • [4] Adult cortical plasticity depends on an early postnatal critical period
    Greenhill, Stuart D.
    Juczewski, Konrad
    de Haan, Annelies M.
    Seaton, Gillian
    Fox, Kevin
    Hardingham, Neil R.
    [J]. SCIENCE, 2015, 349 (6246) : 424 - 427
  • [5] The SORL1 polymorphism rs985421 may confer the risk for amnestic mild cognitive impairment and Alzheimer's disease in the Han Chinese population
    Jin, Chunhui
    Zhang, Lili
    Xian, Yiping
    Liu, Xiaowei
    Wu, Yue
    Zhang, Feng
    Zhu, Jianzhong
    Zhang, Guofu
    Chen, Caixia
    Gong, Ronglan
    Zhang, Lingyun
    Yuan, Jianmin
    Zhang, Fuquan
    Tian, Lin
    Wang, Guoqiang
    Cheng, Zaohuo
    [J]. NEUROSCIENCE LETTERS, 2014, 563 : 80 - 84
  • [6] Effect of DISC1 SNPs on Brain Structure in Healthy Controls and Patients With a History of Psychosis
    Kahler, Anna K.
    Rimol, Lars M.
    Brown, Andrew Anand
    Djurovic, Srdjan
    Hartberg, Cecilie B.
    Melle, Ingrid
    Dale, Anders M.
    Andreassen, Ole A.
    Agartz, Ingrid
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2012, 159B (06) : 722 - 730
  • [7] Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia
    Kang, Eunchai
    Burdick, Katherine E.
    Kim, Ju Young
    Duan, Xin
    Guo, Junjie U.
    Sailor, Kurt A.
    Jung, Dhong-Eun
    Ganesan, Sundar
    Choi, Sungkyung
    Pradhan, Dennis
    Lu, Bai
    Avramopoulos, Dimitrios
    Christian, Kimberly
    Malhotra, Anil K.
    Song, Hongjun
    Ming, Guo-li
    [J]. NEURON, 2011, 72 (04) : 559 - 571
  • [8] Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
    Lichtenstein, Paul
    Yip, Benjamin H.
    Bjork, Camilla
    Pawitan, Yudi
    Cannon, Tyrone D.
    Sullivan, Patrick F.
    Hultman, Christina M.
    [J]. LANCET, 2009, 373 (9659) : 234 - 239
  • [9] New findings support the association of DISCI genetic variants with susceptibility to schizophrenia in the Han Chinese population
    Luo, Xin
    Jin, Chunhui
    Zhou, Zhenhe
    Liu, Xiaowei
    Zhang, Fuquan
    Zhang, Feng
    Zhu, Jianzhong
    Wang, Ying
    Cheng, Zaohuo
    Shugart, Yin Yao
    [J]. PSYCHIATRY RESEARCH, 2015, 228 (03) : 966 - 968
  • [10] Biological insights from 108 schizophrenia-associated genetic loci
    Ripke, Stephan
    Neale, Benjamin M.
    Corvin, Aiden
    Walters, James T. R.
    Farh, Kai-How
    Holmans, Peter A.
    Lee, Phil
    Bulik-Sullivan, Brendan
    Collier, David A.
    Huang, Hailiang
    Pers, Tune H.
    Agartz, Ingrid
    Agerbo, Esben
    Albus, Margot
    Alexander, Madeline
    Amin, Farooq
    Bacanu, Silviu A.
    Begemann, Martin
    Belliveau, Richard A., Jr.
    Bene, Judit
    Bergen, Sarah E.
    Bevilacqua, Elizabeth
    Bigdeli, Tim B.
    Black, Donald W.
    Bruggeman, Richard
    Buccola, Nancy G.
    Buckner, Randy L.
    Byerley, William
    Cahn, Wiepke
    Cai, Guiqing
    Campion, Dominique
    Cantor, Rita M.
    Carr, Vaughan J.
    Carrera, Noa
    Catts, Stanley V.
    Chambert, Kimberly D.
    Chan, Raymond C. K.
    Chen, Ronald Y. L.
    Chen, Eric Y. H.
    Cheng, Wei
    Cheung, Eric F. C.
    Chong, Siow Ann
    Cloninger, C. Robert
    Cohen, David
    Cohen, Nadine
    Cormican, Paul
    Craddock, Nick
    Crowley, James J.
    Curtis, David
    Davidson, Michael
    [J]. NATURE, 2014, 511 (7510) : 421 - +
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