Expedient Metal-Free Synthesis of 1,3-Oxazinen-4-ones

被引：15

作者：

Craig, Alexander J. ^{[1
]}

van der Salm, Louise ^{[1
]}

Stevens-Cullinane, Lars ^{[1
]}

Lucas, Nigel T. ^{[1
]}

Tan, Eng Wui ^{[1
]}

Hawkins, Bill C. ^{[1
]}

机构：

[1] Univ Otago, Dept Chem, Dunedin 9054, New Zealand

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 02期

关键词：

RING-OPENING CYCLIZATIONS; DIELS-ALDER REACTIONS; CARBON-MONOXIDE; CYCLOPROPANES; CYCLOADDITION; REARRANGEMENT; DERIVATIVES; ALDEHYDES; UPENAMIDE; IMINES;

D O I：

10.1021/ol503350h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,3-Oxazinen-4-ones are medicinally important scaffolds which have traditionally been accessed using a hetero-DielsAlder approach or more recently using a cobalt-catalyzed three-component cycloaddition. Herein we report a novel strategy to access this scaffold which allows for the rapid and high yielding synthesis of 1,3-oxazinen-4-ones under ambient temperature and pressures with improved substrate scope.

引用

页码：234 / 237

页数：4

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