Preparation of a 99mTc-labeled graft polymer and its in vitro and in vivo evaluation

被引：5

作者：

Avcibasi, Ugur ^{[1
]}

Turkyarar, Taner ^{[1
]}

Karadag, Aysegul ^{[1
]}

Bakan, Buket ^{[2
,8
]}

Yavasoglu, Nefise Ulku Karabay ^{[2
]}

Kusat, Kevser ^{[3
]}

Akgol, Sinan ^{[4
]}

Gulcemal, Derya ^{[5
]}

Tekin, Volkan ^{[6
]}

Muftuler, Fazilet Zumrut Biber ^{[6
]}

Topal, Gokcen ^{[7
]}

Parlak, Yasemin ^{[7
]}

Gumuser, Fikriye Gul ^{[7
]}

机构：

[1] Manisa Celal Bayar Univ, Fac Art & Sci, Dept Chem, TR-45140 Manisa, Turkey

[2] Ege Univ, Fac Sci, Dept Biol, TR-35100 Izmir, Turkey

[3] Dokuz Eylul Univ, Fac Sci, Dept Chem, TR-35390 Izmir, Turkey

[4] Ege Univ, Fac Sci, Dept Biochem, TR-35100 Izmir, Turkey

[5] Ege Univ, Fac Sci, Dept Chem, TR-35100 Izmir, Turkey

[6] Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, TR-35100 Izmir, Turkey

[7] Manisa Celal Bayar Univ, Sch Med, Dept Nucl Med, Manisa, Turkey

[8] Ataturk Univ, Fac Sci, Dept Mol Biol & Genet, TR-25240 Erzurum, Turkey

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2021年 / 329卷 / 02期

关键词：

Nanopolymer; Graft Polymer; Cytotoxicity; Tc-99m; Radiolabeling; Proline; MAGNETIC NANOPARTICLES; TOXICITY; BIODISTRIBUTION; CYTOTOXICITY; ADSORPTION; DELIVERY; PROLINE; THERAPY; FUTURE; SIZE;

D O I：

10.1007/s10967-021-07817-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The aim of this study is the synthesis of a novel Tc-99m-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with Tc-99m. The radiochemical yield of approximately the Tc-99m-labeled compound amounted to 97 +/- 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.

引用

页码：511 / 525

页数：15

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