Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition

被引：58

作者：

Lahmann, Petra H. ^{[2
,3
]}

Cust, Anne E. ^{[1
,4
]}

Friedenreich, Christine M. ^{[5
]}

Schulz, Mandy ^{[2
]}

Lukanova, Annekatrin ^{[6
]}

Kaaks, Rudolf ^{[6
]}

Lundin, Eva ^{[7
]}

Tjonneland, Anne ^{[8
]}

Halkjaer, Jytte ^{[8
]}

Severinsen, Marianne Tang ^{[9
]}

Overvad, Kim ^{[9
,10
]}

Fournier, Agnes ^{[11
,12
]}

Chabbert-Buffet, Nathalie ^{[11
,12
]}

Clavel-Chapelon, Francoise ^{[11
,12
]}

Dossus, Laure ^{[6
]}

Pischon, Tobias ^{[2
]}

Boeing, Heiner ^{[2
]}

Trichopoulou, Antonia ^{[13
,14
]}

Lagiou, Pagona ^{[13
]}

Naska, Androniki ^{[13
]}

Palli, Domenico ^{[15
]}

Grioni, Sara ^{[16
]}

Mattiello, Amalia ^{[17
]}

Tumino, Rosario ^{[18
,19
]}

Sacerdote, Carlotta ^{[20
,21
]}

Redondo, Maria-Luisa ^{[22
]}

Jakszyn, Paula ^{[23
]}

Sanchez, Maria-Jose ^{[24
,25
]}

Tormo, Maria-Jose ^{[26
,27
]}

Ardanaz, Eva ^{[28
]}

Arriola, Larraitz ^{[29
]}

Manjer, Jonas ^{[30
]}

Jirstrom, Karin ^{[31
,32
]}

Bueno-de-Mesquita, H. Bas ^{[33
]}

May, Anne M. ^{[33
,34
]}

Peeters, Petra H. M. ^{[34
]}

Onland-Moret, N. Charlotte ^{[34
,35
]}

Bingham, Sheila ^{[36
]}

Khaw, Kay-Tee ^{[37
]}

Allen, Naomi E. ^{[38
]}

Spencer, Elizabeth ^{[38
]}

Rinaldi, Sabina ^{[4
]}

Slimani, Nadia ^{[4
]}

Chajes, Veronique ^{[4
]}

Michaud, Dominique ^{[39
]}

Norat, Teresa ^{[39
]}

Riboli, Elio ^{[39
]}

机构：

[1] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Sch Populat Hlth, Melbourne, Vic 3010, Australia

[2] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[3] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

[4] Int Agcy Res Canc, Nutr & Database Resource Team, F-69372 Lyon, France

[5] Alberta Hlth Serv, Div Populat Hlth, Calgary, AB, Canada

[6] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[7] Umea Univ, Umea, Sweden

[8] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[9] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[10] Aarhus Univ Hosp, Aalborg Hosp, Dept Cardiol, Aalborg, Denmark

[11] Inst Gustave Roussy, INSERM, ERI20, F-94805 Villejuif, France

[12] Univ Paris Sud, Inst Gustave Roussy, EA 4045, Villejuif, France

[13] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[14] Hellenic Hlth Fdn, Athens, Greece

[15] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[16] Natl Canc Inst, IRCCS, Nutr Epidemiol Unit, I-20133 Milan, Italy

[17] Univ Naples Federico 2, Dept Clin & Expt Med, Naples, Italy

[18] Civile MP Arezzo Hosp, Dept Oncol, Canc Registry, Ragusa, Italy

[19] Civile MP Arezzo Hosp, Dept Oncol, Histopathol Unit, Ragusa, Italy

[20] Univ Turin, Canc Epidemiol Unit, Turin, Italy

[21] Ctr Canc Epidemiol & Prevent CPO Piemonte, Turin, Italy

[22] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[23] Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[24] Andalusian Sch Publ Hlth, Granada, Spain

[25] CIBERESP, Granada, Spain

[26] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[27] Murcia Med Sch, Prevent Med & Publ Hlth Unit, Murcia, Spain

[28] CIBERESP, Publ Hlth Inst Navarra, Pamplona, Spain

[29] CIBERESP, Basque Govt, Publ Hlth Dept Gipuzkoa, San Sebastian, Spain

[30] Lund Univ, Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[31] Lund Univ, Malmo Univ Hosp, Ctr Mol Pathol, Malmo, Sweden

[32] Lund Univ, CREATE Hlth Ctr Translat Canc Res, Malmo, Sweden

[33] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[34] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[35] Univ Med Ctr Utrecht, Complex Genet Sect, Dept Med Genet DBG, Utrecht, Netherlands

[36] Univ Cambridge, Dept Publ Hlth & Primary Care, MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Cambridge CB2 1TN, England

[37] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Cambridge CB2 2QQ, England

[38] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[39] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2010年 / 126卷 / 10期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

anthropometry; ovarian cancer; etiology; obesity; menopausal status; BODY-MASS INDEX; EPIC-OXFORD PARTICIPANTS; IOWA-WOMENS-HEALTH; UNITED-STATES; PREMENOPAUSAL WOMEN; CIRCULATING LEVELS; SEX STEROIDS; FOLLOW-UP; OBESITY; SIZE;

D O I：

10.1002/ijc.24952

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (as), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m(2), obesity (BMI >= 30 kg/m(2)) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% Cl = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% Cl = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% Cl = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% Cl = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.

引用

页码：2404 / 2415

页数：12

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