Bifunctional ligands for Pd-catalyzed selective alkoxycarbonylation of alkynes

被引：30

作者：

Qi, Huimin ^{[1
,2
]}

Huang, Zijun ^{[1
]}

Wang, Menglan ^{[1
]}

Yang, Peiju ^{[1
]}

Du, Chen-Xia ^{[3
]}

Chen, Shu-Wei ^{[2
]}

Li, Yuehui ^{[1
]}

机构：

[1] Chinese Acad Sci, LICP, Ctr Excellence Mol Synth, Suzhou Res Inst LICP,State Key Lab Oxo Synth & Se, Lanzhou 730000, Gansu, Peoples R China

[2] Northwest A&F Univ, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China

[3] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China

来源：

JOURNAL OF CATALYSIS | 2018年 / 363卷

关键词：

Carbonylation; Alkyne; Palladium; Bifunctional ligand; Unsaturated ester; PAUSON-KHAND REACTION; PALLADIUM CATALYST; UNSATURATED ESTERS; CARBONYLATION; METHOXYCARBONYLATION; ACETYLENE; ALKENES; HYDROFORMYLATION; MECHANISM; OLEFINS;

D O I：

10.1016/j.jcat.2018.04.007

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Catalytic carbonylations of alkynes represent straightforward and atom-economic synthesis of a, beta-unsaturated carbonyl compounds. One of the issues associated with the currently known catalytic systems is insufficient efficiency. In this context, Pd/ligand-catalyzed regioselective and efficient alkoxycarbonylation of terminal alkynes is desirable for the synthesis of alpha,beta-unsaturated esters. Herein, we present the use of a newly designed bifunctional ligand for efficient Pd-catalyzed alkoxycarbonylation of alkynes. Both aliphatic and aromatic alkynes were smoothly transformed to the branched desired products with high selectivity (28 examples, 45-96% yields, 95.0-99.9% selectivity). (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：63 / 68

页数：6

共 39 条

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