Activity of omadacycline tested against Enterobacteriaceae causing urinary tract infections from a global surveillance program (2014)

Omadacycline is an aminomethylcycline with in vitro activity against many gram-negative pathogens. Omadacycline and comparators were tested against Enterobacteriaceae from urinary tract infections (UTIs) selected from a 2014 global surveillance program and compared to results of isolates from 2010 surveillance. The omadacycline MIC50/60 for Enterobacteriaceae collected during 2014 was 2/>= 8 mu g/mL (1/4 mu g/mL minus Proteus, Providencia, and Morganella spp.). The MIC50/90 for E. coli was 1/2 mu g/mL, similar to that in 2010 (MIC50/60, 0.5/2 mu g/mL). The MICs for 91.7% of Klebsiella spp. isolates in 2014 (89.7%, 2010) were <= 4 mu g/mL. In 2010 and 2014, a total of 100.0% and 95.8% of ESBL screen-positive (SP) phenotype E. coli and 73.9% and 75.0% of ESBL SP Klebsiella spp., respectively, exhibited MIC values at <= 4 mu g/mL. Omadacycline was active against UTI-causing Enterobacteriaceae isolates from NA and EU. Further study of omadacycline to treat UTIs caused by Enterobacteriaceae may be indicated. (C) 2018 Elsevier Inc. All rights reserved.