Two polyoxometalate-based coordination polymers: Synthesis, characterization and in vitro anti-lung cancer activity

被引：2
作者：
Wu, Lei [1 ,2 ]
Wang, Ling-ling [3 ]
Li, Hui [1 ]
机构：
[1] Capital Med Univ, Beijing Chao Yang Hosp, Dept Thorac Surg, Beijing, Peoples R China
[2] Jilin City Cent Hosp, Dept Thorac Surg, Jilin, Jilin, Peoples R China
[3] Beihua Univ, Affiliated Hosp, Dept Neurol, Jilin, Jilin, Peoples R China
来源：
MAIN GROUP CHEMISTRY | 2019年 / 18卷 / 04期
关键词：
Polyoxometalate; coordination polymer; MTT assay; anticancer activity;
D O I：
10.3233/MGC-180740
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two novel coordination polymers based on alpha-Keggin-type polyoxometalate, [Cu(L-1)(2)] [H3BW12O40]center dot 8H(2)O (1, L-1 = 1,4-bis((H-1-imidazol-1-yl)methyl)benzene) and [Zn2Mn(H2O)(6)(L-1)(4)] [BW12O40]center dot NO3 center dot 4H(2)O (2), have been solvothermally synthesized and characterized by single-crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD) along with the elemental analysis (EA). In addition, in vitro anticancer activity of compounds 1 and 2 on three human lung cancer cells (NCI-H292, NCI-H460 and LTEP-A-2) was further determined via the MTT (3-(4,5-dimethyl-2-thioazolyl)-2,5-diphenyl tetrazolium bromide) assay.
引用
收藏
页码：337 / 344
页数：8
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