Direct Presentation Is Sufficient for an Efficient Anti-Viral CD8+ T Cell Response

被引：50

作者：

Xu, Ren-Huan ^{[1
]}

Remakus, Sanda ^{[1
]}

Ma, Xueying ^{[1
]}

Roscoe, Felicia ^{[1
]}

Sigal, Luis J. ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

来源：

PLOS PATHOGENS | 2010年 / 6卷 / 02期

关键词：

ANTIGEN-PRESENTING CELLS; CLASS-I COMPLEXES; CROSS-PRESENTATION; DENDRITIC CELLS; VACCINIA VIRUS; LYMPHOCYTE RESPONSES; GENERATION; INFECTION; IMMUNITY; CTL;

D O I：

10.1371/journal.ppat.1000768

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The extent to which direct-and cross-presentation (DP and CP) contribute to the priming of CD8(+) T cell (TCD8+) responses to viruses is unclear mainly because of the difficulty in separating the two processes. Hence, while CP in the absence of DP has been clearly demonstrated, induction of an anti-viral TCD8+ response that excludes CP has never been purposely shown. Using vaccinia virus (VACV), which has been used as the vaccine to rid the world of smallpox and is proposed as a vector for many other vaccines, we show that DP is the main mechanism for the priming of an anti-viral TCD8+ response. These findings provide important insights to our understanding of how one of the most effective anti-viral vaccines induces immunity and should contribute to the development of novel vaccines.

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页数：9

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