Molecules with versatile biological activities bearing antipyrinyl nucleus as pharmacophore

被引：32

作者：

Sahoo, Jyotirmaya ^{[1
,5
]}

Sahoo, Chita Ranjan ^{[2
,3
,4
]}

Sarangi, Priyambada Kshiroda Nandini ^{[5
]}

Prusty, Shakti Ketan ^{[6
]}

Padhy, Rabindra Nath ^{[3
,4
]}

Paidesetty, Sudhir Kumar ^{[2
]}

机构：

[1] ARKA Jain Univ, Sch Pharm, Jameshedpur 832108, Jharkand, India

[2] Siksha O Anusandhan, Sch Pharmaceut Sci, Dept Med Chem, Bhubaneswar 751003, Odisha, India

[3] Siksha O Anusandhan, Cent Res Lab, Inst Med Sci, Bhubaneswar 751003, Odisha, India

[4] Siksha O Anusandhan, Sum Hosp, Bhubaneswar 751003, Odisha, India

[5] Sri Jayadev Coll Pharmaceut Sci, Dept Pharmaceut Chem, Bhubaneswar 752101, Odisha, India

[6] Siksha O Anusandhan, Sch Pharmaceut Sci, Dept Pharmaceut Pharmacol, Bhubaneswar 751003, Odisha, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 186卷

关键词：

Antipyrine; Pyrazolone; Schiffbase; Synthesis; COPPER(II) COMPLEXES; ANTIMICROBIAL ACTIVITY; OXIDATIVE STRESS; SCHIFF-BASES; SPECTRAL CHARACTERIZATION; ANTIOXIDANT ACTIVITY; IN-SILICO; 4-AMINOANTIPYRINE; ANTIBACTERIAL; NI(II);

D O I：

10.1016/j.ejmech.2019.111911

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antipyrine (1,2-dihydro-1,5-dimethyl-2-phenylpyrazole-3-one) in a structural frame consists of a five membered lactam pyrazolone heterocyclic ring as a pharmacophore moiety. It is evident from literature that the molecules having nitrogen bearing heterocyclic nuclei clearly exhibit several biological actions. Commercially available pyrazolone derivatives as drugs, analgin and metamizol are an established chemical class of analgesics. Recent trends of synthetic routes and several biological actions of antipyrine analogues are considered in this review. Indeed, the synthesized derivatives possess antipyrine moiety having versatile biological properties, antimicrobial, antitubercular, anthelmintic, antioxidant, analgesic, anti-inflammatory, cytotoxic and antiviral activities. (C) 2019 Elsevier Masson SAS. All rights reserved.

引用

页数：22

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