Synthesis of Isoquinolines through IrIII-Catalyzed C-H Activation/Annulation from Benzimidates with Hydroxylisopropylalkynes

被引：16

作者：

Liu, Mingliang ^{[1
,2
]}

Gong, Wanchun ^{[2
]}

You, Erli ^{[2
]}

Zhang, Haizhen ^{[2
]}

Shi, Lei ^{[2
]}

Cao, Weiguo ^{[1
,3
]}

Shi, Jingjing ^{[2
]}

机构：

[1] Shanghai Univ, Sch Environm & Chem Engn, 99 Shangda Rd, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China

[3] Shanghai Univ, Dept Chem, Innovat Drug Res Ctr, 99 Shangda Rd, Shanghai 200444, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 36期

关键词：

Annulation; C-H activation; Iridium; Nitrogen heterocycles; Synthetic methods; ONE-POT SYNTHESIS; OXIDATIVE ANNULATION; ACTIVATION; AMIDATION; ALKYNES; ACCESS; ALPHA; DERIVATIVES; MILD; RH;

D O I：

10.1002/ejoc.201800410

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An Ir-III-catalyzed cascade reaction consisting of C-H activation/annulation of benzimidates with hydroxylisopropylalkynes is reported. A broad range of isoquinolines has been prepared in one step with good functiona-group tolerance and high efficiency.

引用

页码：4991 / 4995

页数：5

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