Choline chloride derivative-based deep eutectic liquids as novel green alternative solvents for extraction of phenolic compounds from olive leaf

被引:136
作者
Alanon, M. E. [1 ,2 ]
Ivanovic, M. [3 ]
Gomez-Caravaca, A. M. [1 ,2 ]
Arraez-Roman, D. [1 ,2 ]
Segura-Carretero, A. [1 ,2 ]
机构
[1] Univ Granada, Fac Sci, Dept Analyt Chem, C Fuentenueva S-N, E-18071 Granada, Spain
[2] PTS Granada, Res & Dev Funct Food Ctr CIDAF, Avda Conocimiento 37,Bioreg Bldg, Granada 18016, Spain
[3] Univ Maribor, Fac Chem & Chem Engn, Lab Analyt Chem & Ind Anal, Smetanova Ul 17, SI-2000 Maribor, Slovenia
关键词
Deep eutectic solvents; Green chemistry; Olive leaf; Phenolic compounds; Microwave assisted extraction; HPLC-DAD-ESI-TOF-MS; MICROWAVE-ASSISTED EXTRACTION; ANTHOCYANINS; OPTIMIZATION; OLEUROPEIN; MEDIA; OIL;
D O I
10.1016/j.arabjc.2018.01.003
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In the presented study, a new methodology based on the use of deep eutectic solvents (DESs) and microwave-assisted extraction (MAE) and subsequent analysis by HPLC-DAD-ESI-TOF-MS was proposed for the extraction of phenolic compounds from olive leaf. Nine different DESs, using choline chloride as hydrogen bond acceptor in combination with different hydrogen bond donors (four polyalcohols, three organic acids, one sugar and urea), were firstly scanned. A total of 48 phenolic compounds were identified in the olive leaf using HPLC-DAD-ESI-TOF-MS. Experimental results and multivariate data analysis pointed to choline chloride-ethyleneglycol as being the most effective within the tested DESs, showing extraction yields similar to those exhibited by conventional solvents. A Box-Behnken Design and response surface methodology were applied with the aim to optimize the main parameters involved in the extraction process. The optimal extraction conditions were 79.6 degrees C of temperature, 43.3% of water and 16.7 min of irradiation time. Correlation coefficients (R-2 > 0.98) indicated a good relationship between experimental data and the fitted quadratic term models. Results indicated that DESs could be a sustainable alternative to traditional solvents for the extraction of bioactive compounds among many other applications. (C) 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码:1685 / 1701
页数:17
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