New Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases

被引：86
作者：
Zhang, Xueyan [1 ,2 ]
Ding, Ming [1 ,3 ]
Zhu, Ping [4 ]
Huang, Huanlei [4 ]
Zhuang, Quan [5 ]
Shen, Jie [1 ]
Cai, Yufeng [1 ,6 ]
Zhao, Mingyi [1 ]
He, Qingnan [1 ]
机构：
[1] Cent South Univ, Xiangya Hosp 3, Dept Pediat, Changsha 410013, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Sch Publ Hlth, Changsha 410013, Hunan, Peoples R China
[4] Guangdong Acad Med Sci, Guangdong Cardiovasc Inst, Guangdong Prov Peoples Hosp, Guangzhou 510100, Guangdong, Peoples R China
[5] Cent South Univ, Xiangya Hosp 3, Transplantat Ctr, Changsha 410013, Hunan, Peoples R China
[6] Cent South Univ, Xiangya Sch Life Sci, Changsha 410013, Hunan, Peoples R China
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2019年 / 2019卷
基金：
中国国家自然科学基金;
关键词：
NF-KAPPA-B; OXIDATIVE STRESS; LUNG INJURY; NRF2; ACTIVATION; CELLS; FERROPTOSIS; INDUCTION; APOPTOSIS; PATHWAY;
D O I：
10.1155/2019/3214196
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Respiratory diseases are one of the most common pediatric diseases in clinical practice. Their pathogenesis, diagnosis, and treatment are thus worthy of further investigation. The nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) signaling axis is a multiple organ protection chain that protects against oxidative stress injury. This signaling axis regulates anti-inflammation and antioxidation by regulating calcium ions, mitochondrial oxidative stress, autophagy, ferroptosis, pyroptosis, apoptosis, alkaliptosis, and clockophagy. This review presents an overview of the role of the Nrf2/HO-1 signaling axis in the pathogenesis of pediatric respiratory diseases and the latest research progress on this subject. Overall, the Nrf2/HO-1 signaling axis has an important clinical value in pediatric respiratory diseases, and its protective effect needs further exploration.
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页数：9
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