Pravastatin-loaded chitosan nanoparticles: Formulation, characterization and cytotoxicity studies

被引：26

作者：

Badran, Mohamed M. ^{[1
,4
]}

Harisa, Gamaleldin I. ^{[2
,5
]}

AlQahtani, Saeed A. ^{[2
]}

Alanazi, Fars K. ^{[2
]}

Zoheir, Khairy M. A. ^{[3
,6
]}

机构：

[1] King Saud Univ, Dept Pharmaceut, Coll Pharm, Bldg 23,Off AA 68,POB 2457, Riyadh 11451, Saudi Arabia

[2] King Saud Univ, Dept Pharmaceut, Coll Pharm, Pharmaceut Ind, POB 2457, Riyadh 11451, Saudi Arabia

[3] King Saud Univ, Coll Pharm, Dept Pharmacol, Riyadh, Saudi Arabia

[4] Al Azhar Univ, Coll Pharm, Dept Pharmaceut, Cairo, Egypt

[5] Al Azhar Univ, Coll Pharm, Dept Biochem, Cairo, Egypt

[6] Natl Res Ctr, Dept Cell Biol, Cairo, Egypt

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2016年 / 32卷

关键词：

Chitosan nanoparticles; Pravastatin; Characterization; In vitro release; Cytotoxicity; DRUG-DELIVERY; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; TUMOR; THERAPY; RELEASE; ERYTHROCYTES; NANOGELS; SURVIVAL; SODIUM;

D O I：

10.1016/j.jddst.2016.01.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pravastatin (PRV) loaded Chitosan nanoparticles (PRV/CSNPs) were employed as a novel carriers for liver cancer treatment. These nanoparticles were prepared by an ionic gelation method and characterized by FTIR and XRD. The prepared nanoparticles showed the spherical shape of nanoparticles having an average size of 129.8 +/- 10.5-270.4 +/- 23.3 nm, PDI in the range of 0.238 +/- 0.03-0.452 +/- 0.05 and zeta potential between 25.1 +/- 2.6 and 33.5 +/- 2.7 mV. The PRV entrapment efficiency of CSNPs was in the range of 49.05-72.04%. The in vitro release studies showed an initial rapid PRV release up to 6 h followed by a slow release ranging from 52 to 92% after 48 h following Higuchi's model kinetics. The in vitro cytotoxicity of PRV/CSNPs showed 51% HepG2 growth inhibition compared to 38% of free PRV after 72 h incubation. PRV/CSNPs can be considered as a promising carrier for cancer therapy. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：1 / 9

页数：9

共 45 条

[1]

Abdel-Hamid M, 2012, ASIAN J CHEM, V24, P584

[2] Chitin and chitosan in selected biomedical applications [J].