Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography

被引：12

作者：

Kim, Sanghoon ^{[1
]}

Heflin, Stephanie ^{[2
]}

Kresty, Laura A. ^{[3
]}

Halling, Meredith ^{[3
]}

Perez, Laura N. ^{[3
]}

Ho, Derek

Crose, Michael ^{[1
]}

Brown, William ^{[1
]}

Farsiu, Sina ^{[2
]}

Arshavsky, Vadim ^{[2
]}

Wax, Adam ^{[1
]}

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[2] Duke Univ, Dept Ophthalmol, Durham, NC 27708 USA

[3] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 04期

关键词：

NUCLEAR MORPHOLOGY MEASUREMENTS; LIGHT-SCATTERING; OCT;

D O I：

10.1364/BOE.7.001400

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Angle-resolved low coherence interferometry (a/LCI) is an optical technique used to measure nuclear morphology in situ. However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissue architecture. Here we present a 2D a/LCI system which incorporates optical coherence tomography imaging to guide the measurements. System design and characterization are presented, along with example cases which demonstrate the utility of the combined measurements. In addition, future development and applications of this dual modality approach are discussed. (C) 2016 Optical Society of America

引用

页码：1400 / 1414

页数：15

共 29 条

[11] Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography
Liu, Linbo
Gardecki, Joseph A.
Nadkarni, Seemantini K.
Toussaint, Jimmy D.
Yagi, Yukako
Bouma, Brett E.
Tearney, Guillermo J.
[J]. NATURE MEDICINE, 2011, 17 (08) : 1010 - U132
[12] Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen
Liu, Tan
Wei, Qing
Wang, Jing
Jiao, Shuliang
Zhang, Hao F.
[J]. BIOMEDICAL OPTICS EXPRESS, 2011, 2 (05): : 1359 - 1365
[13] Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue
Maher, Jason R.
Chuchuen, Oranat
Henderson, Marcus H.
Kim, Sanghoon
Rinehart, Matthew T.
Kashuba, Angela D. M.
Wax, Adam
Katz, David F.
[J]. BIOMEDICAL OPTICS EXPRESS, 2015, 6 (06): : 2022 - 2035
[14] Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry
Pyhtila, John W.
Ma, Hongwei
Simnick, Andrew J.
Chilkoti, Ashutosh
Wax, Adam
[J]. JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (03)
[15] Interferometric synthetic aperture microscopy
Ralston, Tyler S.
Marks, Daniel L.
Carney, P. Scott
Boppart, Stephen A.
[J]. NATURE PHYSICS, 2007, 3 (02) : 129 - 134
[16] Modeling Light Scattering in Tissue as Continuous Random Media Using a Versatile Refractive Index Correlation Function
Rogers, Jeremy D.
Radosevich, Andrew J.
Yi, Ji
Backman, Vadim
[J]. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2014, 20 (02)
[17] Automatic segmentation of up to ten layer boundaries in SD-OCT images of the mouse retina with and without missing layers due to pathology
Srinivasan, Pratul P.
Heflin, Stephanie J.
Izatt, Joseph A.
Arshavsky, Vadim Y.
Farsiu, Sina
[J]. BIOMEDICAL OPTICS EXPRESS, 2014, 5 (02): : 348 - 365
[18] Detection of intestinal dysplasia using angle-resolved low coherence interferometry
Terry, Neil
Zhu, Yizheng
Thacker, Julie K. M.
Migaly, John
Guy, Cynthia
Mantyh, Christopher R.
Wax, Adam
[J]. JOURNAL OF BIOMEDICAL OPTICS, 2011, 16 (10)
[19] Detection of Dysplasia in Barrett's Esophagus With In Vivo Depth-Resolved Nuclear Morphology Measurements
Terry, Neil G.
Zhu, Yizheng
Rinehart, Matthew T.
Brown, William J.
Gebhart, Steven C.
Bright, Stephanie
Carretta, Elizabeth
Ziefle, Courtney G.
Panjehpour, Masoud
Galanko, Joseph
Madanick, Ryan D.
Dellon, Evan S.
Trembath, Dimitri
Bennett, Ana
Goldblum, John R.
Overholt, Bergein F.
Woosley, John T.
Shaheen, Nicholas J.
Wax, Adam
[J]. GASTROENTEROLOGY, 2011, 140 (01) : 42 - 50
[20] Tuchin V., 2000, TISSUE OPTICS

← 1 2 3 →