共 23 条
Cutting edge: Involvement of the type IIFN production and signaling pathway in lipopolysaccharide-induced IL-10 production
被引:184
作者:

Chang, Elmer Y.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

Guo, Beichu
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

Doyle, Sean E.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

Cheng, Genhong
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
机构:
[1] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Div Digest Dis, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Specialty Training Adv Res Program, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA
关键词:
D O I:
10.4049/jimmunol.178.11.6705
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Macrophages respond to LPS hy the rapid activation of proinflammatory cytokines that serve to initiate host defense against microbial invasion. To prevent injury to the host from excess production of these cytokines, IL-10 is upregulated to feedback inhibit the proinflammatory response. However, the molecular events responsible for LPS-induced up-regulation of IL-10 remain to be elucidated. In this study, we provide evidence that production of and signaling by type IIFN is required for LPS-induced IL-10 up-regulation. In addition, we demonstrate that defect in type I IFN production and signaling results in a trend toward LPS-mediated superinduction of proinflammatory genes and cytokines in bone marrow-derived macrophages. Our findings suggest a novel antiinflammatory role for the type I IFN production and signaling pathway in regulating LPS response in bone marrow-derivedmacrophages.
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页码:6705 / 6709
页数:5
相关论文
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