The promise of epigenetic therapy: reprogramming the cancer epigenome

被引：122

作者：

Kelly, Andrew D. ^{[1
]}

Issa, Jean-Pierre J. ^{[1
]}

机构：

[1] Temple Univ, Lewis Katz Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19140 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2017年 / 42卷

关键词：

ACUTE MYELOID-LEUKEMIA; T-CELL LYMPHOMA; BET BROMODOMAIN INHIBITION; HEMATOPOIETIC STEM-CELLS; DNA METHYLATION; HUMAN GENOME; MYELODYSPLASTIC SYNDROMES; MALIGNANT-TRANSFORMATION; COLORECTAL-CANCER; SOMATIC MUTATIONS;

D O I：

10.1016/j.gde.2017.03.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epigenetics refers to heritable molecular determinants of phenotype independent of DNA sequence. Epigenetic features include DNA methylation, histone modifications, non-coding RNAs, and chromatin structure. The epigenetic status of cells plays a crucial role in determining their differentiation state and proper function within multicellular organisms. Disruption of these processes is now understood to be a major contributor to cancer development and progression, and recent efforts have attempted to pharmacologically reverse such altered epigenetics. In this mini-review we introduce the concept of epigenetic drivers of cancer and discuss how aberrant DNA methylation, histone modifications, and chromatin states are being targeted using drugs either in preclinical, or clinical development, and how they fit in the context of existing therapies.

引用

页码：68 / 77

页数：10

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