The Impact of Simulated Weightlessness on Endothelium-Dependent Angiogenesis and the Role of Caveolae/Caveolin-1

被引：23
|
作者：
Shi, Fei [1 ]
Zhao, Tian-Zhi [2 ]
Wang, Yong-Chun [1 ]
Cao, Xin-Sheng [1 ]
Yang, Chang-Bin [1 ]
Gao, Yuan [1 ]
Li, Cheng-Fei [1 ]
Zhao, Jiang-Dong [1 ]
Zhang, Shu [1 ]
Sun, Xi-Qing [1 ]
机构：
[1] Fourth Mil Med Univ, Fac Aerosp Med, Dept Aerosp Biodynam, 169 Changle Xi Rd, Xian 710032, Shanxi, Peoples R China
[2] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian 710032, Shanxi, Peoples R China
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2016年 / 38卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Simulated microgravity; Endothelial cells; Angiogenesis; Caveolin-1; eNOS; NITRIC-OXIDE SYNTHASE; ORTHOSTATIC INTOLERANCE; BED-REST; MICROGRAVITY; CELLS; CAVEOLIN; MECHANISMS; SPACEFLIGHT; PROTEIN; NOS;
D O I：
10.1159/000438646
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Background/Aims: The potential role of caveolin-1 in modulating angiogenesis in microgravity environment is unexplored. Methods: Using simulated microgravity by clinostat, we measured the expressions and interactions of caveolin-1 and eNOS in human umbilical vein endothelial cells. Results: We found that decreased caveolin-1 expression is associated with increased expression and phosphorylation levels of eNOS in endothelial cells stimulated by microgravity, which causes a dissociation of eNOS from caveolin-1 complexes. As a result, microgravity induces cell migration and tube formation in endothelial cell in vitro that depends on the regulations of caveolin-1. Conclusion: Our study provides insight for the important endothelial functions in altered gravitational environments. (C) 2016 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码：502 / 513
页数：12
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