Application of urine proteomics for biomarker discovery in drug-induced liver injury

被引：32

作者：

van Swelm, Rachel P. L. ^{[1
]}

Kramers, Cornelis ^{[1
]}

Masereeuw, Rosalinde ^{[1
]}

Russel, Frans G. M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Pharmacol & Toxicol, NL-6500 HB Nijmegen, Netherlands

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 2014年 / 44卷 / 10期

关键词：

acetaminophen; diclofenac; fibrosis; gel electrophoresis; hepatocellular injury; idiosyncratic; LC-MS/MS; MALDI-TOF MS; methotrexate; oxidative stress; AMOXICILLIN-CLAVULANIC ACID; INDUCED HEPATIC-INJURY; INDUCED FULMINANT-HEPATITIS; DICLOFENAC-ASSOCIATED HEPATOTOXICITY; CARBON-TETRACHLORIDE HEPATOTOXICITY; MURINE ACETAMINOPHEN HEPATOTOXICITY; TAMOXIFEN-INDUCED STEATOHEPATITIS; NEUTROPHIL DEPLETION PROTECTS; LATENT TUBERCULOSIS INFECTION; FLIGHT MASS-SPECTROMETRY;

D O I：

10.3109/10408444.2014.931341

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The leading cause of hepatic damage is drug-induced liver injury (DILI), for which currently no adequate predictive biomarkers are available. Moreover, for most drugs related to DILI, the mechanisms underlying the adverse reaction have not yet been elucidated. Urinary protein biomarker candidates for DILI have emerged in the past few years and correlate well with clinical studies for serum DILI biomarkers. The goal of this review was to investigate the use of urine as a source of protein biomarkers for drug-induced liver injury. Finally, we discuss some of the current strategies required to advance the field of biomarker discovery for DILI with respect to appropriate clinical biobanking and adequate translational research.

引用

页码：823 / 841

页数：19

共 302 条

[1] Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury
Abdelmegeed, Mohamed A.
Jang, Sehwan
Banerjee, Atrayee
Hardwick, James P.
Song, Byoung-Joon
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2013, 60 : 211 - 222
[2] Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity
Abdelmegeed, Mohamed A.
Moon, Kwan-Hoon
Chen, Chi
Gonzalez, Frank J.
Song, Byoung-Joon
[J]. BIOCHEMICAL PHARMACOLOGY, 2010, 79 (01) : 57 - 66
[3] ACTIS GC, 1995, LIVER, V15, P320
[4] Mechanisms of Immune-Mediated Liver Injury
Adams, David H.
Ju, Cynthia
Ramaiah, Shashi K.
Uetrecht, Jack
Jaeschke, Hartmut
[J]. TOXICOLOGICAL SCIENCES, 2010, 115 (02) : 307 - 321
[5] Assessment of candidate biomarkers of drug-induced hepatobiliary injury in preclinical toxicity studies
Adler, M.
Hoffmann, D.
Ellinger-Ziegelbauer, H.
Hewitt, P.
Matheis, K.
Mulrane, L.
Gallagher, W. M.
Callanan, J. J.
Suter, L.
Fountoulakis, M. M.
Dekant, W.
Mally, A.
[J]. TOXICOLOGY LETTERS, 2010, 196 (01) : 1 - 11
[6] Tamoxifen-induced hepatotoxicity
Ahbeddou, N.
Belbaraka, R.
Fetohi, M.
Errihani, H.
[J]. INDIAN JOURNAL OF CANCER, 2011, 48 (03)
[7] Liver Fatty Acid-binding Protein Is A Diagnostic Marker to Detect Liver Injury Due to Chronic Hepatitis C Infection
Akbal, Erdem
Koklu, Seyfettin
Kocak, Erdem
Cakal, Basak
Gunes, Fahri
Basar, Omer
Tuna, Yasar
Senes, Mehmet
[J]. ARCHIVES OF MEDICAL RESEARCH, 2013, 44 (01) : 34 - 38
[8] Alam I, 1996, AM J GASTROENTEROL, V91, P1626
[9] Phenytoin-induced toxic cholestatic hepatitis in a patient with skin lesions:: Case report
Altuntas, Y
Öztürk, B
Erdem, L
Günes, G
Karul, S
Uçak, S
Sengül, A
[J]. SOUTHERN MEDICAL JOURNAL, 2003, 96 (02) : 201 - 203
[10] The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury
Amacher, David E.
[J]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2012, 8 (03) : 335 - 347

← 1 2 3 4 5 6 7 8 9 10 →