Fertility Preservation for Prepubertal Patients at Risk of Infertility: Present Status and Future Perspectives

被引：26
作者：
Pampanini, Valentina [1 ,2 ,3 ]
Hassan, Jasmin [3 ,4 ]
Oliver, Elizabeth [2 ,3 ]
Stukenborg, Jan-Bernd [2 ,3 ]
Damdimopoulou, Pauliina [3 ,4 ]
Jahnukainen, Kirsi [2 ,3 ,5 ,6 ]
机构：
[1] Osped Pediat Bambino Gesu, Dipartimento Pediat Univ Osped, Rome, Italy
[2] Karolinska Inst, NORDFERTIL Res Lab Stockholm, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden
[3] Karolinska Univ Hosp, Stockholm, Sweden
[4] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynecol, Stockholm, Sweden
[5] Univ Helsinki, Childrens Hosp, Div Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland
[6] Helsinki Univ Hosp, Helsinki, Finland
来源：
HORMONE RESEARCH IN PAEDIATRICS | 2021年 / 93卷 / 11-12期
基金：
芬兰科学院;
关键词：
Fertility preservation; Childhood; Cryopreservation; Cancer; STEM-CELL TRANSPLANTATION; PREMATURE OVARIAN INSUFFICIENCY; ALKYLATING AGENT EXPOSURE; CHILDHOOD-CANCER; ADULT SURVIVORS; FEMALE SURVIVORS; IN-VITRO; TESTICULAR TISSUE; SPERM; PREGNANCY;
D O I：
10.1159/000516087
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The increasing cure rate of cancer has led to a vast population of survivors having to face the late adverse effects of oncological treatments, with fertility impairment being one of the most sensitive issues for patients. Different options to preserve the fertility of adult patients are routinely used in clinical practice. However, fertility preservation strategies for prepubertal patients at risk of infertility are limited to the cryopreservation of immature gonadal tissue. In recent decades, many research efforts have been focused on the future use of cryopreserved gonadal tissue. This review discusses the common status of fertility preservation measures for pediatric patients undergoing gonadotoxic treatment, focusing especially on the challenges that remain to be solved in order to implement this fundamental service.
引用
收藏
页码：599 / 608
页数：10
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