Cardiopulmonary interactions in children with congenital heart disease: physiology and clinical correlates

被引：9

作者：

Kocis, KC ^{[1
]}

Meliones, JN ^{[1
]}

机构：

[1] Univ So Calif, Sch Med, Childrens Hosp Los Angeles, Dept Pediat & Surg, Los Angeles, CA 90027 USA

来源：

PROGRESS IN PEDIATRIC CARDIOLOGY | 2000年 / 11卷 / 03期

关键词：

cardiac output; cardiopulmonary interactions; children; congenital cardiac disease; fontan operation; high frequency jet ventilation; intrathoracic pressure; mechanical ventilation; positive pressure ventilation; pulmonary vascular resistance; ventricular interdependence;

D O I：

10.1016/S1058-9813(00)00051-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiopulmonary interaction is the term that is used to describe the inseparable connection between the heart and lungs. In health, the cardiovascular and pulmonary systems are in perfect balance. Ln disease, derangements of either system leads to dysfunction in the other. Physicians attempt to improve health with therapeutic interventions (positive pressure ventilation) typically aimed at treating disease (pneumonia with hypoxia) in one system (lungs) with resultant positive (recruitment of alveoli) and negative (ventilator induced lung injury) consequences and secondary impact on the other system (heart with decreased cardiac output). This manuscript will review the physiologic basis of normal cardiopulmonary interactions and the pathophysiology that occurs in specific disease processes affecting children with congenital cardiac disease. Lastly, we will present current data highlighting therapeutic interventions aimed at improving cardiopulmonary interactions. (C) 2000 Elsevier Science ireland Ltd. All rights reserved.

引用

页码：203 / 210

页数：8

共 47 条

[1] Combined effects of nitric oxide and oxygen during acute pulmonary vasodilator testing [J].