Protease-Sensitive Nanomaterials for Cancer Therapeutics and Imaging

被引：48
作者：
Anderson, Caleb F. [1 ,2 ]
Cui, Honggang [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Johns Hopkins Univ, Dept Chem & Biomol Engn, 3400 North Charles St, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, Inst NanoBioTechnol, 3400 North Charles St, Baltimore, MD 21218 USA
[3] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA
[5] Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Ctr Nanomed, 400 North Broadway, Baltimore, MD 21231 USA
来源：
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2017年 / 56卷 / 20期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
PHOTODYNAMIC THERAPY AGENT; IN APOPTOSIS SENSOR; DRUG-DELIVERY; MULTIFUNCTIONAL NANOPARTICLES; ENZYME-ACTIVITY; THERANOSTIC NANOPARTICLES; MATRIX METALLOPROTEINASES; ENGINEERED NANOPARTICLES; CONTROLLED-RELEASE; PANCREATIC-CANCER;
D O I：
10.1021/acs.iecr.7b00990
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Many diseases can be characterized by the abnormal activity exhibited by various biomolecules, the targeting of which can provide therapeutic and diagnostic utility. Recent trends in medicine and nanotechnology have prompted the development of protease sensitive nanomaterials systems for therapeutic, diagnostic, and theranostic applications. These systems can act specifically in response to the target enzyme and its associated disease conditions, thus enabling personalized treatment and improved prognosis. In this Review, we discuss recent advancements in the development of protease-responsive materials for imaging and drug delivery and analyze several representative systems to illustrate their key design principles.
引用
收藏
页码：5761 / 5777
页数：18
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