Proceedings from the Second Haploidentical Stem Cell Transplantation-Symposium Haplo2014, San Francisco, California, December 4, 2014

被引：7

作者：

Al Malki, Monzr M. ^{[1
]}

Horowitz, Mary ^{[2
]}

Handgretinger, Rupert ^{[3
]}

Leung, Wing ^{[4
]}

Roy, Denis-Claude ^{[5
]}

Huang, Xiao-Jun ^{[6
]}

Fuchs, Ephraim ^{[7
]}

Locatelli, France ^{[8
]}

Blaise, Didier ^{[9
]}

Mineishi, Shin ^{[10
]}

Martelli, Massimo ^{[11
]}

Miller, Jeffrey ^{[12
]}

June, Carl ^{[13
]}

Ai, Hui-sheng ^{[14
]}

Luznik, Leo ^{[7
]}

Mavilio, Domenico ^{[15
]}

Lugli, Enrico ^{[15
]}

van den Brink, Marcel R. M. ^{[16
]}

Champlin, Richard E. ^{[17
]}

Ciurea, Stefan O. ^{[17
]}

机构：

[1] City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

[2] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA

[3] Children Univ Hosp, Tubingen, Germany

[4] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA

[5] Univ Montreal, Montreal, PQ, Canada

[6] Peking Univ, Inst Hematol, Beijing 100871, Peoples R China

[7] Johns Hopkins Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

[8] Bambino Gesu Pediat Hosp, Rome, Italy

[9] Inst J Paoli I Calmettes, F-13009 Marseille, France

[10] Univ Alabama Birmingham, Birmingham, AL USA

[11] Univ Perugia, I-06100 Perugia, Italy

[12] Univ Minnesota, Minneapolis, MN USA

[13] Univ Penn, Philadelphia, PA 19104 USA

[14] Acad Mil Med Sci, Affiliated Hosp, Beijing, Peoples R China

[15] Humanitas Clin & Res Ctr, Milan, Italy

[16] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[17] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2016年 / 22卷 / 04期

关键词：

Haploidentical transplantation; Post-transplantation cyclophosphamide; T cell depleted; Immunologic reconstitution after transplantation; Cellular therapy; ACUTE MYELOID-LEUKEMIA; NATURAL-KILLER-CELLS; BONE-MARROW-TRANSPLANTATION; RELAPSE-FREE SURVIVAL; REGULATORY T-CELLS; NK CELLS; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE; HEMATOLOGIC MALIGNANCIES; ALTERNATIVE DONORS; HEMATOPOIETIC TRANSPLANTATION;

D O I：

10.1016/j.bbmt.2016.01.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Significant progress has been made over the past decade in haploidentical transplantation, with the development of novel methods to control intense alloreactive reactions generated in the major HLA-mismatched setting. Application of post-transplantation cyclophosphamide has gained worldwide acceptance as an effective and low-cost way to perform this type of transplantation, with outcomes now similar to those from HLA-matched unrelated donors. These advances have resulted in improved treatment-related mortality, whereas disease relapse has emerged as the most common cause of treatment failure. In addition, improvements in immunologic reconstitution after transplantation are much needed, not only in haploidentical transplantation but in all forms of stem cell transplantation. This symposium has focused on some of the most promising methods to control alloreactivity in this form of transplantation and application of cellular therapy to prevent disease relapse after transplantation, as well as understanding immunologic reconstitution and foreseeable approaches to improve immune recovery after transplantation. (C) 2016 American Society for Blood and Marrow Transplantation.

引用

页码：594 / 604

页数：11

共 83 条

[1] γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes [J].

Airoldi, Irma ;

Bertaina, Alice ;

Prigione, Ignazia ;

Zorzoli, Alessia ;

Pagliara, Daria ;

Cocco, Claudia ;

Meazza, Raffaella ;

Loiacono, Fabrizio ;

Lucarelli, Barbarella ;

Bernardo, Maria Ester ;

Barbarito, Giulia ;

Pende, Daniela ;

Moretta, Alessandro ;

Pistoia, Vito ;

Moretta, Lorenzo ;

Locatelli, Franco .

BLOOD, 2015, 125 (15) :2349-2358

[2] Contrasting Effects of Anti-Ly49A Due to MHC Class I cis Binding on NK Cell-Mediated Allogeneic Bone Marrow Cell Resistance [J].

Alvarez, Maite ;

Sungur, Can M. ;

Ames, Erik ;

Anderson, Stephen K. ;

Pomeroy, Claire ;

Murphy, William J. .

JOURNAL OF IMMUNOLOGY, 2013, 191 (02) :688-698

[3]

[Anonymous], BLOOD

[4] Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype [J].

Aversa, F ;

Tabilio, A ;

Velardi, A ;

Cunningham, I ;

Terenzi, A ;

Falzetti, F ;

Ruggeri, L ;

Barbabietola, G ;

Aristei, C ;

Latini, P ;

Reisner, Y ;

Martelli, MF .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (17) :1186-1193

[5] Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein [J].

Bachanova, Veronika ;

Cooley, Sarah ;

Defor, Todd E. ;

Verneris, Michael R. ;

Zhang, Bin ;

McKenna, David H. ;

Curtsinger, Julie ;

Panoskaltsis-Mortari, Angela ;

Lewis, Dixie ;

Hippen, Keli ;

McGlave, Philip ;

Weisdorf, Daniel J. ;

Blazar, Bruce R. ;

Miller, Jeffrey S. .

BLOOD, 2014, 123 (25) :3855-3863

[6] T-Cell-Replete HLA-Haploidentical Hematopoietic Transplantation for Hematologic Malignancies Using Post-Transplantation Cyclophosphamide Results in Outcomes Equivalent to Those of Contemporaneous HLA-Matched Related and Unrelated Donor Transplantation [J].

Bashey, Asad ;

Zhang, Xu ;

Sizemore, Connie A. ;

Manion, Karen ;

Brown, Stacey ;

Holland, H. Kent ;

Morris, Lawrence E. ;

Solomon, Scott R. .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (10) :1310-1316

[7] HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders [J].

Bertaina, Alice ;

Merli, Pietro ;

Rutella, Sergio ;

Pagliara, Daria ;

Bernardo, Maria Ester ;

Masetti, Riccardo ;

Pende, Daniela ;

Falco, Michela ;

Handgretinger, Rupert ;

Moretta, Francesca ;

Lucarelli, Barbarella ;

Brescia, Letizia P. ;

Li Pira, Giuseppina ;

Testi, Manuela ;

Cancrini, Caterina ;

Kabbara, Nabil ;

Carsetti, Rita ;

Finocchi, Andrea ;

Moretta, Alessandro ;

Moretta, Lorenzo ;

Locatelli, Franco .

BLOOD, 2014, 124 (05) :822-826

[8] HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease [J].

Bolanos-Meade, Javier ;

Fuchs, Ephraim J. ;

Luznik, Leo ;

Lanzkron, Sophie M. ;

Gamper, Christopher J. ;

Jones, Richard J. ;

Brodsky, Robert A. .

BLOOD, 2012, 120 (22) :4285-4291

[9] Different Proliferative Potential and Migratory Characteristics of Human CD4+ Regulatory T Cells That Express either CD45RA or CD45R0 [J].

Booth, Nicola J. ;

McQuaid, Arthur J. ;

Sobande, Toni ;

Kissane, Steve ;

Agius, Elaine ;

Jackson, Sarah E. ;

Salmon, Mike ;

Falciani, Francesco ;

Yong, Kwee ;

Rustin, Malcolm H. ;

Akbar, Arne N. ;

Vukmanovic-Stejic, Milica .

JOURNAL OF IMMUNOLOGY, 2010, 184 (08) :4317-4326

[10] RETRACTED: Natural soluble Interleukin-15Rα is generated by cleavage that involves the tumor necrosis factor-α-converting enzyme (TACE/ADAM17) (Retracted Article. See vol 286, pg 9894, 2011) [J].

Budagian, V ;

Bulanova, E ;

Orinska, Z ;

Ludwig, A ;

Rose-John, S ;

Saftig, P ;

Borden, EC ;

Bulfone-Paus, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (39) :40368-40375

← 1 2 3 4 5 6 7 8 9 →