Human Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium in Retinal Treatment: from Bench to Bedside

被引：10
作者：
Parvini, Maryam [1 ]
Satarian, Leila [2 ]
Parivar, Kazem [1 ]
Javan, Mohammad [2 ,3 ]
Tondar, Mahdi [2 ]
Ahmad, Sajjad [4 ]
Baharvand, Hossein [2 ,5 ]
机构：
[1] Islamic Azad Univ, Dept Biol, Sci & Res Branch, Tehran, Iran
[2] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Stem Cells & Dev Biol, Tehran, Iran
[3] Tarbiat Modares Univ, Fac Med Sci, Dept Physiol, Tehran, Iran
[4] Univ Liverpool, Dept Eye & Vis Sci, Liverpool L69 3BX, Merseyside, England
[5] Univ Sci & Culture, ACECR, Dept Dev Biol, Tehran, Iran
来源：
MOLECULAR NEUROBIOLOGY | 2014年 / 50卷 / 02期
关键词：
Cell therapy; Ocular diseases; Pluripotent stem cells; Retinal pigmented epithelium; EARLY EYE DEVELOPMENT; LONG-TERM SAFETY; SEE VOL. 511; DIRECTED DIFFERENTIATION; EXTRACELLULAR-MATRIX; SOMATIC-CELLS; MACULAR DEGENERATION; SELF-ORGANIZATION; DIRECT CONVERSION; SMALL MOLECULES;
D O I：
10.1007/s12035-014-8684-y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The generation of retinal pigment epithelial (RPE) cells from pluripotent stem cells is a topic of interest over the past few years as dysfunctional RPE cells are a primary cause of ocular diseases. However, a number of obstacles need to be overcome before these cells can be used in clinical trials. This review aims to provide an overview of the latest reports on the generation of RPE cells from human pluripotent stem cells. Challenges that need to be addressed in future studies for their therapeutic applications are discussed. Proposed research goals for this fast growing field are highlighted.
引用
收藏
页码：597 / 612
页数：16
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