Human Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium in Retinal Treatment: from Bench to Bedside

被引：10
作者：
Parvini, Maryam [1 ]
Satarian, Leila [2 ]
Parivar, Kazem [1 ]
Javan, Mohammad [2 ,3 ]
Tondar, Mahdi [2 ]
Ahmad, Sajjad [4 ]
Baharvand, Hossein [2 ,5 ]
机构：
[1] Islamic Azad Univ, Dept Biol, Sci & Res Branch, Tehran, Iran
[2] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Stem Cells & Dev Biol, Tehran, Iran
[3] Tarbiat Modares Univ, Fac Med Sci, Dept Physiol, Tehran, Iran
[4] Univ Liverpool, Dept Eye & Vis Sci, Liverpool L69 3BX, Merseyside, England
[5] Univ Sci & Culture, ACECR, Dept Dev Biol, Tehran, Iran
来源：
MOLECULAR NEUROBIOLOGY | 2014年 / 50卷 / 02期
关键词：
Cell therapy; Ocular diseases; Pluripotent stem cells; Retinal pigmented epithelium; EARLY EYE DEVELOPMENT; LONG-TERM SAFETY; SEE VOL. 511; DIRECTED DIFFERENTIATION; EXTRACELLULAR-MATRIX; SOMATIC-CELLS; MACULAR DEGENERATION; SELF-ORGANIZATION; DIRECT CONVERSION; SMALL MOLECULES;
D O I：
10.1007/s12035-014-8684-y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The generation of retinal pigment epithelial (RPE) cells from pluripotent stem cells is a topic of interest over the past few years as dysfunctional RPE cells are a primary cause of ocular diseases. However, a number of obstacles need to be overcome before these cells can be used in clinical trials. This review aims to provide an overview of the latest reports on the generation of RPE cells from human pluripotent stem cells. Challenges that need to be addressed in future studies for their therapeutic applications are discussed. Proposed research goals for this fast growing field are highlighted.
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收藏
页码：597 / 612
页数：16
相关论文
共 137 条
[1]   The Path from Skin to Brain: Generation of Functional Neurons from Fibroblasts [J].
Abdullah, Aisha Iman ;
Pollock, Andrew ;
Sun, Tao .
MOLECULAR NEUROBIOLOGY, 2012, 45 (03) :586-595
[2]   Nonviral Direct Conversion of Primary Mouse Embryonic Fibroblasts to Neuronal Cells [J].
Adler, Andrew F. ;
Grigsby, Christopher L. ;
Kulangara, Karina ;
Wang, Hong ;
Yasuda, Ryohei ;
Leong, Kam W. .
MOLECULAR THERAPY-NUCLEIC ACIDS, 2012, 1 :e32
[3]   Generation of pluripotent stem cells from adult mouse liver and stomach cells [J].
Aoi, Takashi ;
Yae, Kojiro ;
Nakagawa, Masato ;
Ichisaka, Tomoko ;
Okita, Keisuke ;
Takahashi, Kazutoshi ;
Chiba, Tsutomu ;
Yamanaka, Shinya .
SCIENCE, 2008, 321 (5889) :699-702
[4]   Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells [J].
Araki, Ryoko ;
Uda, Masahiro ;
Hoki, Yuko ;
Sunayama, Misato ;
Nakamura, Miki ;
Ando, Shunsuke ;
Sugiura, Mayumi ;
Ideno, Hisashi ;
Shimada, Akemi ;
Nifuji, Akira ;
Abe, Masumi .
NATURE, 2013, 494 (7435) :100-104
[5]   Phototoxic Action Spectrum on a Retinal Pigment Epithelium Model of Age-Related Macular Degeneration Exposed to Sunlight Normalized Conditions [J].
Arnault, Emilie ;
Barrau, Coralie ;
Nanteau, Celine ;
Gondouin, Pauline ;
Bigot, Karine ;
Vienot, Francoise ;
Gutman, Emmanuel ;
Fontaine, Valerie ;
Villette, Thierry ;
Cohen-Tannoudji, Denis ;
Sahel, Jose-Alain ;
Picaud, Serge .
PLOS ONE, 2013, 8 (08)
[6]   Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6 [J].
Bäumer, N ;
Marquardt, T ;
Stoykova, A ;
Spieler, D ;
Treichel, D ;
Ashery-Padan, R ;
Gruss, P .
DEVELOPMENT, 2003, 130 (13) :2903-2915
[7]   Transplantation of the RPE in AMD [J].
Binder, Susanne ;
Stanzel, Boris V. ;
Krebs, Ilse ;
Glittenberg, Carl .
PROGRESS IN RETINAL AND EYE RESEARCH, 2007, 26 (05) :516-554
[8]  
Bora N, 1998, DEV DYNAM, V213, P283, DOI 10.1002/(SICI)1097-0177(199811)213:3<283::AID-AJA5>3.0.CO
[9]  
2-H
[10]   Evaluation of Differential Toxicity of Varying Doses of Bevacizumab on Retinal Ganglion Cells, Retinal Pigment Epithelial Cells, and Vascular Endothelial Growth Factor-Enriched Choroidal Endothelial Cells [J].
Brar, Vikram S. ;
Sharma, Rajesh K. ;
Murthy, Ravi K. ;
Chalam, Kakarla V. .
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 2009, 25 (06) :507-511
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