Post-transfusion purpura (PTP) associated with anti-HPA-1a, anti-HPA-2b and anti-HPA-3a antibodies

被引：12

作者：

Lucas, GF

Pittman, SJ

Davies, S

Solanki, T

Bruggemann, K

机构：

[1] Int Blood Grp, Reference Lab, Bristol BS10 5ND, Avon, England

[2] Musgrave Pk Hosp, Dept Haematol, Taunton, MA USA

[3] Musgrave Pk Hosp, Dept Care Elderly, Taunton, MA USA

来源：

TRANSFUSION MEDICINE | 1997年 / 7卷 / 04期

关键词：

anti-HPA-1a; anti-HPA-2b; anti-HPA-3a; PTP;

D O I：

10.1046/j.1365-3148.1997.d01-39.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The serum from an 85-year-old man with a clinical diagnosis of post-transfusion purpura (PTP) was investigated for the presence of platelet-specific antibodies. Clinically, the case was typical of PTP but, unusually, the serum was found to contain multiple platelet-specific alloantibodies. Anti-HPA-1a, anti-HPA-2b and anti-HPA-3a antibodies were detected together with multispecific anti-HLA (class I) antibodies. Additional (but weaker) antibody reactivity was also observed with platelet glycoproteins (Gp) IIb/IIIa, GpIb and GpIa/IIa which lacked the antigens recognized by the alloantibodies, suggesting the presence of auto-or cross-reacting antibodies. The patient's genotype was HPA-1b/1b, HPA-2a/2a, HPA-3b/3b, HPA-5a/5b and was consistent with the platelet alloantibodies detected. The patient made a complete recovery following treatment with intravenous gamma-globulin.

引用

页码：295 / 299

页数：5

共 15 条

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