Photocatalyzed Csp3-Csp3 cross-dehydrogenative coupling of N-Boc-tetrahydroisoquinolines with α,β-unsaturated ketones

被引：5

作者：

Ao, Na-Ri-Mei ^{[1
]}

Zhu, Xue-Qing ^{[1
]}

Zhao, Chun-Xin ^{[1
]}

Gao, Ya-Ru ^{[1
]}

Wang, Yong-Qiang ^{[1
]}

机构：

[1] Northwest Univ, Coll Chem & Mat Sci, Natl Demonstrat Ctr Expt Chem Educ, Key Lab Synthet & Nat Funct Mol Chem,Minist Educ, Xian 710069, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 21期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1039/d1ob00527h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel photocatalyzed cross-dehydrogenative coupling reaction of N-Boc-tetrahydroisoquinolines with alpha,beta-unsaturated ketones has been developed. This research provides an easy access to a variety of C1-substituted tetrahydroisoquinolines, which can be further transformed into benzo[a]-quinolizine-2-ones, the skeletons of natural products with a wide range of biological activities. The load of the photocatalyst is low and the oxidant is inexpensive and less toxic.

引用

收藏

页码：4752 / 4759

页数：8

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