The synthesis of morusin as a potent antitumor agent

被引：47

作者：

Tseng, Tsui-Hwa ^{[1
]}

Chuang, Shien-Kai ^{[1
]}

Hu, Chao-Chin ^{[1
]}

Chang, Chia-Fu ^{[2
]}

Huang, Yu-Chao ^{[2
]}

Lin, Cheng-Wei ^{[2
]}

Lee, Yean-Jang ^{[2
]}

机构：

[1] Chung Shan Med Univ, Sch Appl Chem, Taichung 402, Taiwan

[2] Natl Changhua Univ Educ, Dept Chem, Changhua 50058, Taiwan

来源：

TETRAHEDRON | 2010年 / 66卷 / 06期

关键词：

Morusin; ErSLi; SnCl(2); CULTIVATED MULBERRY TREE; P-METHOXYBENZYL ETHERS; ACID PHENETHYL ESTER; C6; GLIOMA-CELLS; PRENYLATED FLAVONOIDS; ARACHIDONATE; 5-LIPOXYGENASE; HUMULUS-LUPULUS; TRIMETHYL ETHER; ALBA L; CANCER;

D O I：

10.1016/j.tet.2009.12.002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Morusin. which call be isolated from Chinese herbal medicine. is achieved in which the longest linear sequence is only 13 steps in 12% overall yield from commercially available phloroglucinol In addition, the metal/EtSH reagents for regioselective demethylation of polymethylated morusin were described Consequently this strategy provided a concise route 10 synthesize the morusin analogues as well Further biological studies of morusin. it exhibited strong antitumor effects with IC(50) similar to 3 0 mu M oil three cancel cells (C) 2009 Elsevier Ltd All rights reserved

引用

页码：1335 / 1340

页数：6

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