A PEGylated photosensitizer-core pH-responsive polymeric nanocarrier for imaging-guided combination chemotherapy and photodynamic therapy†

被引：12
作者：
Chang, Zhijian [1 ]
Ye, Jia-Hai [1 ]
Qi, Fen [2 ]
Fang, Hongbao [2 ]
Lin, Fuyan [1 ]
Wang, Shuai [1 ]
Mu, Cancan [1 ]
Zhang, Wenchao [1 ]
He, Weijiang [2 ]
机构：
[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China
[2] Nanjing Univ, State Key Lab Coordinat Chem, Sch Chem & Chem Engn, Nanjing 210093, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 14期
基金：
中国国家自然科学基金;
关键词：
MESOPOROUS SILICA NANOPARTICLES; DRUG-DELIVERY; CONJUGATED POLYELECTROLYTE; ANTICANCER DRUG; VESICLES; MICELLES; CARRIERS; THERANOSTICS; STRATEGY; PRODRUG;
D O I：
10.1039/d0nj04461j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel chemo-photodynamic combined therapeutic self-assembly polymeric platform (MPEG-Hyd-Br-2-BODIPY) was constructed based on 2,6-diBr-BODIPY as the photosensitizer core and MPEG as the hydrophilic side chain through hydrazone bond linkage which can successfully encapsulate DOX and exhibited an accelerated release rate with decreasing pH value from 7.4 to 5.0 which results in considerable time/dose-dependent cytotoxicity. In addition, the photosensitizer moieties embedded in MPEG-Hyd-Br-2-BODIPY could generate singlet oxygen (O-1(2)) effectively under light irradiation, which was expected to realize the synchronization therapy of chemo- and photodynamic therapy (PDT).
引用
收藏
页码：6180 / 6185
页数：6
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