Fruitful Decades for Canthin-6-ones from 1952 to 2015: Biosynthesis, Chemistry, and Biological Activities

被引：32
作者：
Dai, Jiangkun [1 ]
Li, Na [1 ]
Wang, Junru [1 ]
Schneider, Uwe [2 ]
机构：
[1] Northwest A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China
[2] Univ Edinburgh, EaStCHEM Sch Chem, Kings Bldg,David Brewster Rd, Edinburgh EH9 3FJ, Midlothian, Scotland
来源：
MOLECULES | 2016年 / 21卷 / 04期
基金：
中国国家自然科学基金;
关键词：
canthin-6-one; biosynthesis; chemistry; biological activities; BETA-CARBOLINE ALKALOIDS; CHILOPERONE VAR. ANGUSTIFOLIUM; CATALYZED AMIDATION REACTION; NITRIC-OXIDE PRODUCTION; EURYCOMA-LONGIFOLIA; ZANTHOXYLUM-CHILOPERONE; AILANTHUS-ALTISSIMA; 5,5-DISUBSTITUTED 4,5-DIHYDRO-6H-CANTHIN-6-ONES; ANTIPROLIFERATIVE ACTIVITY; ANTIMALARIAL CONSTITUENTS;
D O I：
10.3390/molecules21040493
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, more than 60 natural canthin-6-one alkaloids and their structures are considered. The biosynthesis, efficient and classic synthetic approaches, and biological activities of canthin-6-one alkaloids, from 1952 to 2015, are discussed. From an analysis of their structural properties and an investigation of the literature, possible future trends for canthin-6-one alkaloids are proposed. The information reported will be helpful in future research on canthin-6-one alkaloids.
引用
收藏
页数：13
相关论文
共 81 条
[61]   Discovery of novel DNA gyrase inhibitors by high-throughput virtual screening [J].
Ostrov, David A. ;
Prada, Jose A. Hernandez ;
Corsino, Patrick E. ;
Finton, Kathryn A. ;
Le, Nhan ;
Rowe, Thomas C. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (10) :3688-3698
[62]   Synthesis and Cytotoxic Activity of New β-Carboline Derivatives [J].
Peduto, A. ;
More, V. ;
de Caprariis, P. ;
Festa, M. ;
Capasso, A. ;
Piacente, S. ;
De Martino, L. ;
De Feo, V. ;
Filosa, R. .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2011, 11 (06) :486-491
[63]   A Convenient Approach to the Canthin-4-one Ring System: Total Synthesis of the Alkaloids Tuboflavine and Norisotuboflavine [J].
Puzik, Andreas ;
Bracher, Franz .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2009, 46 (04) :770-773
[64]   Cytotoxic constituents of the twigs of Simaroubla glauca collected from a plot in southern Florida [J].
Rivero-Cruz, JF ;
Lezutekong, R ;
Lobo-Echeverri, T ;
Ito, A ;
Mi, QW ;
Chai, HB ;
Soejarto, DD ;
Cordell, GA ;
Pezzuto, JM ;
Swanson, SM ;
More, I ;
Kinghorn, AD .
PHYTOTHERAPY RESEARCH, 2005, 19 (02) :136-140
[65]  
Rosenkranz H.J., 1966, LIEBIGS ANN CHEM, V691, P159
[66]  
Rössler U, 1999, TETRAHEDRON LETT, V40, P7075
[67]   Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors [J].
Sasaki, Tatsunori ;
Li, Wei ;
Higai, Koji ;
Koike, Kazuo .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (09) :1979-1981
[68]  
Shi M.J., 2000, CHIN TRADIT HERBA DR, V31, P37
[69]   Progress in the Synthesis of Canthine Alkaloids and Ring-Truncated Congeners [J].
Showalter, H. D. Hollis .
JOURNAL OF NATURAL PRODUCTS, 2013, 76 (03) :455-467
[70]   Baylis-Hillman Reaction of 1-Formyl-β-carboline: One-Step Synthesis of the Canthin-6-one Framework by an Unprecedented Cascade Cyclization Reaction [J].
Singh, Virender ;
Hutait, Samiran ;
Batra, Sanjay .
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2009, 2009 (35) :6211-6216
123456789