Replicative senescence in the immune system: Impact of the hayflick limit on T-cell function in the elderly

被引：81
作者：
Effros, RB [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Pathol & Lab Med, Sch Med, Los Angeles, CA 90095 USA
来源：
AMERICAN JOURNAL OF HUMAN GENETICS | 1998年 / 62卷 / 05期
关键词：
D O I：
10.1086/301845
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
[No abstract available]
引用
收藏
页码：1003 / 1007
页数：5
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共 31 条
[1]   Lifespans of T lymphocytes [J].
Adibzadeh, M ;
Mariani, E ;
Bartoloni, C ;
Beckman, I ;
Ligthart, G ;
Remarque, E ;
Shall, S ;
Solana, R ;
Taylor, GM ;
Barnett, Y ;
Pawelec, G .
MECHANISMS OF AGEING AND DEVELOPMENT, 1996, 91 (02) :145-154
[2]  
AZUMA M, 1993, J IMMUNOL, V150, P1147
[3]   The genetics of cellular senescence [J].
Bérubé, NG ;
Smith, JR ;
Pereira-Smith, OM .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (05) :1015-1019
[4]   Extension of life-span by introduction of telomerase into normal human cells [J].
Bodnar, AG ;
Ouellette, M ;
Frolkis, M ;
Holt, SE ;
Chiu, CP ;
Morin, GB ;
Harley, CB ;
Shay, JW ;
Lichtsteiner, S ;
Wright, WE .
SCIENCE, 1998, 279 (5349) :349-352
[5]   Mechanism of telomerase induction during T cell activation [J].
Bodnar, AG ;
Kim, NW ;
Effros, RB ;
Chiu, CP .
EXPERIMENTAL CELL RESEARCH, 1996, 228 (01) :58-64
[6]  
Campisi Judith, 1996, P121
[7]   Immune dysfunction in Down's syndrome: Primary immune deficiency or early senescence of the immune system? [J].
Cuadrado, E ;
Barrena, MJ .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1996, 78 (03) :209-214
[8]   DECLINE IN CD28(+) T-CELLS IN CENTENARIANS AND IN LONG-TERM T-CELL CULTURES - A POSSIBLE CAUSE FOR BOTH IN-VIVO AND IN-VITRO IMMUNOSENESCENCE [J].
EFFROS, RB ;
BOUCHER, N ;
PORTER, V ;
ZHU, XM ;
SPAULDING, C ;
WALFORD, RL ;
KRONENBERG, M ;
COHEN, D ;
SCHACHTER, F .
EXPERIMENTAL GERONTOLOGY, 1994, 29 (06) :601-609
[9]   GENERATION OF BOTH CROSS-REACTIVE AND VIRUS-SPECIFIC T-CELL POPULATIONS AFTER IMMUNIZATION WITH SEROLOGICALLY DISTINCT INFLUENZA-A VIRUSES [J].
EFFROS, RB ;
DOHERTY, PC ;
GERHARD, W ;
BENNINK, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1977, 145 (03) :557-568
[10]   Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion? [J].
Effros, RB ;
Pawelec, G .
IMMUNOLOGY TODAY, 1997, 18 (09) :450-454
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