Seroprevalence of SARS-CoV-2 antibodies in university students: Cross-sectional study, December 2020, England

被引：22

作者：

Vusirikala, Amoolya ^{[1
]}

Whitaker, Heather ^{[1
]}

Jones, Samuel ^{[1
]}

Tessier, Elise ^{[1
]}

Borrow, Ray ^{[2
]}

Linley, Ezra ^{[2
]}

Hoschler, Katja ^{[1
]}

Baawuah, Frances ^{[1
]}

Ahmad, Shazaad ^{[3
]}

Andrews, Nick ^{[1
]}

Ramsay, Mary ^{[1
]}

Ladhani, Shamez N. ^{[1
,4
]}

Brown, Kevin E. ^{[1
]}

Amirthalingam, Gayatri ^{[1
]}

机构：

[1] Publ Hlth England, Immunisat & Countermeasures Div, 61 Colindale Ave, London NW9 5EQ, England

[2] Publ Hlth England, Serowpidemiol Unit, Publ Hlth Lab Manchester, Manhcester Royal Infirm,Manchester Med Microbiol, Oxford Rd, Manchester M13 9WL, Lancs, England

[3] Manchester Fdn Trust, Manchester Acad Hlth Sci Ctr, Dept Virol, Manchester Med Microbiol Partnership, Manchester M13 9WL, Lancs, England

[4] St Georges Univ London, Paediat Infect Dis Res Grp, London SW17 0RE, England

来源：

JOURNAL OF INFECTION | 2021年 / 83卷 / 01期

关键词：

SARS-CoV-2; infection; COVID-19; Universities; Transmission; Students;

D O I：

10.1016/j.jinf.2021.04.028

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: In England, the reopening of universities in September 2020 coincided with a rapid increase in SARS-CoV-2 infection rates in university aged young adults. This study aimed to estimate SARS-CoV-2 antibody prevalence in students attending universities that had experienced a COVID-19 outbreak after reopening for the autumn term in September 2020. Methods: A cross-sectional serosurvey was conducted during 02-11 December 2020 in students aged <= 25 yearsacross five universities in England. Blood samples for SARS-CoV-2 antibody testing were obtained using a self-sampling kit and analysed using the Abbott SARS-CoV-2 N antibody and/or an in-house receptor binding domain (RBD) assay. Findings: SARS-CoV-2 seroprevalence in 2,905 university students was 17.8% (95%CI, 16.5-19.3), ranging between 7.6%-29.7% across the five universities. Seropositivity was associated with being younger likely to represent first year undergraduates (aOR 3.2, 95% CI 2.0-4.9), living in halls of residence (aOR 2.1, 95% CI 1.7-2.7) and sharing a kitchen with an increasing number of students (shared with 4-7 individuals, aOR 1.43, 95%CI 1.12-1.82; shared with 8 or more individuals, aOR 1.53, 95% CI 1.04-2.24). Seropositivity was 49% in students living in halls of residence that reported high SARS-CoV-2 infection rates (>8%) during the autumn term. Interpretation: Despite large numbers of cases and outbreaks in universities, less than one in five students (17.8%) overall had SARS-CoV- 2 antibodies at the end of the autumn term in England. In university halls of residence affected by a COVID-19 outbreak, however, nearly half the resident students became infected and developed SARS-CoV-2 antibodies. Crown Copyright (C) 2021 Published by Elsevier Ltd on behalf of The British Infection Association. All rights reserved.

引用

页码：104 / 111

页数：8

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