Asymmetric Synthesis of Allenyl α-Amino Amides by an Isothiourea Catalyzed Enantioselective [2,3]-Sigmatropic Rearrangement

被引：16

作者：

Zhang, Ling ^{[1
]}

Zhang, Zi-Jing ^{[1
]}

Xiao, Jing-Yu ^{[1
]}

Song, Jin ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 17期

基金：

中国博士后科学基金;

关键词：

ALLYLIC AMMONIUM YLIDES; ACYL TRANSFER CATALYST; KINETIC RESOLUTION; SIGMATROPIC REARRANGEMENTS; CLAISEN REARRANGEMENT; ACYLAMMONIUM SALTS; PROPARGYL SULFIDES; ORGANIC-SYNTHESIS; ORGANOCATALYSIS; DERIVATIVES;

D O I：

10.1021/acs.orglett.8b02521

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly efficient catalytic asymmetric [2,3]-sigmatropic rearrangements of propargyl ammonium salts have been accomplished under mild reaction conditions. In the presence of the chiral isothiourea catalyst, a wide range of allenyl a-amino amide derivatives were obtained in generally good yields (up to 99%) with excellent enantioselectivities (up to 96% ee).

引用

页码：5519 / 5522

页数：4

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